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Journal of Medicinal Chemistry|October 24, 2012
Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329)James S Scott, Joanne deSchoolmeester, Elaine Kilgour, et al.Journal of Molecular Biology|December 21, 2010
Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratopeDavid C Lowe, Stefan Gerhardt, Alison Ward, et al.Bioorganic & Medicinal Chemistry Letters|June 15, 2011
Selective non zinc binding inhibitors of MMP13Chris De Savi, Andrew D Morley, Attilla Ting, et al.Journal of Medicinal Chemistry|June 14, 2012
Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017)James S Scott, Suzanne S Bowker, Joanne Deschoolmeester, et al.Journal of Medicinal Chemistry|May 21, 2024
Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion MutationsClare Thomson, Peter Barton, Erin Braybrooke, et al.Cell Reports. Medicine|August 26, 2025
AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertionsAisha M Swaih, Sara Talbot, Adriana Savoca, et al.Journal of Molecular Biology|October 20, 2009
Structure of IL-17A in complex with a potent, fully human neutralizing antibodyStefan Gerhardt, W Mark Abbott, David Hargreaves, et al.Journal of Medicinal Chemistry|June 25, 2024
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, et al.Journal of Medicinal Chemistry|September 18, 2024
Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 InhibitorsSimon C C Lucas, J Henry Blackwell, Ulf Börjesson, et al.Journal of Medicinal Chemistry|September 28, 2024
Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion MutationsClare Thomson, Erin Braybrooke, Nicola Colclough, et al.Pageof 4