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Scientific Reports|December 2, 2015
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)Kim Huard, Janice Brown, Jessica C Jones, et al.ACS Medicinal Chemistry Letters|December 1, 2015
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic TreatmentMark Ammirati, Scott W Bagley, Samit K Bhattacharya, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical CandidateSamit K Bhattacharya, Kim Andrews, Ramsay Beveridge, et al.Journal of Medicinal Chemistry|December 30, 2021
Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1Agustin Casimiro-Garcia, Christophe Allais, Agnes Brennan, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 AgonistsDavid W Piotrowski, Kentaro Futatsugi, Joseph S Warmus, et al.Journal of Medicinal Chemistry|March 25, 2010
Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humansMark I Lansdell, David Hepworth, Andrew Calabrese, et al.Science (New York, N.Y.)|April 25, 2024
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cellsFabian Offensperger, Gary Tin, Miquel Duran-Frigola, et al.Journal of Medicinal Chemistry|October 29, 2015
Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular DiseasesRoger B Ruggeri, Leonard Buckbinder, Scott W Bagley, et al.Journal of Medicinal Chemistry|September 9, 2015
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)Kentaro Futatsugi, Daniel W Kung, Suvi T M Orr, et al.Plos One|September 22, 2017
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assayJustin Hall, Amy Brault, Fabien Vincent, et al.Pageof 5