Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Filters

David J Huggins

Showing results (41-50 of 65) with videos related to

Pageof 7
Sort By:
Nature Communications|May 26, 2021
Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissuesNathaniel Kastan, Ksenia Gnedeva, Theresa Alisch, et al.
ACS Bio & Med Chem Au|December 25, 2023
Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase InhibitorsMayako Michino, Alexandre Beautrait, Nicholas A Boyles, et al.
Nature Communications|February 14, 2023
On-demand male contraception via acute inhibition of soluble adenylyl cyclaseMelanie Balbach, Thomas Rossetti, Jacob Ferreira, et al.
Chemical Communications (Cambridge, England)|August 9, 2017
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interactionDaniel J Cole, Matej Janecek, Jamie E Stokes, et al.
Scientific Reports|November 6, 2019
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregationPooja Sharma, Robert Mahen, Maxim Rossmann, et al.
Proteins|September 15, 2006
Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormonesMichel Cusson, Catherine Béliveau, Stephanie E Sen, et al.
Proceedings of the National Academy of Sciences of the United States of America|July 22, 2022
Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organsNathaniel R Kastan, Sanyukta Oak, Rui Liang, et al.
ACS Medicinal Chemistry Letters|September 17, 2025
Discovery of Novel Isofunctional SARS-CoV‑2 NSP14 RNA Cap Methyltransferase Inhibitors by Structure-Based Virtual ScreeningCindy Meyer, Mayako Michino, David J Huggins, et al.
Journal of Chemical Information and Modeling|April 15, 2023
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy PerturbationShan Sun, Makoto Fushimi, Thomas Rossetti, et al.
Scientific Reports|June 25, 2016
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2Matej Janeček, Maxim Rossmann, Pooja Sharma, et al.
Pageof 7

Showing results (41-50 of 65) with videos related to

Sort By:
Pageof 7
Nature Communications|May 26, 2021
Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissuesNathaniel Kastan, Ksenia Gnedeva, Theresa Alisch, et al.
ACS Bio & Med Chem Au|December 25, 2023
Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase InhibitorsMayako Michino, Alexandre Beautrait, Nicholas A Boyles, et al.
Nature Communications|February 14, 2023
On-demand male contraception via acute inhibition of soluble adenylyl cyclaseMelanie Balbach, Thomas Rossetti, Jacob Ferreira, et al.
Chemical Communications (Cambridge, England)|August 9, 2017
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interactionDaniel J Cole, Matej Janecek, Jamie E Stokes, et al.
Scientific Reports|November 6, 2019
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregationPooja Sharma, Robert Mahen, Maxim Rossmann, et al.
Proteins|September 15, 2006
Characterization and tissue-specific expression of two lepidopteran farnesyl diphosphate synthase homologs: implications for the biosynthesis of ethyl-substituted juvenile hormonesMichel Cusson, Catherine Béliveau, Stephanie E Sen, et al.
Proceedings of the National Academy of Sciences of the United States of America|July 22, 2022
Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organsNathaniel R Kastan, Sanyukta Oak, Rui Liang, et al.
ACS Medicinal Chemistry Letters|September 17, 2025
Discovery of Novel Isofunctional SARS-CoV‑2 NSP14 RNA Cap Methyltransferase Inhibitors by Structure-Based Virtual ScreeningCindy Meyer, Mayako Michino, David J Huggins, et al.
Journal of Chemical Information and Modeling|April 15, 2023
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy PerturbationShan Sun, Makoto Fushimi, Thomas Rossetti, et al.
Scientific Reports|June 25, 2016
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2Matej Janeček, Maxim Rossmann, Pooja Sharma, et al.
Pageof 7