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ACS Medicinal Chemistry Letters
|
March 18, 2022
A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors
Rui Liang, Daisuke Tomita, Yusuke Sasaki, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 23, 2019
Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells
Edouard Mullarky, Jiayi Xu, Anita D Robin, et al.
ACS Medicinal Chemistry Letters
|
April 17, 2024
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable <i>In Vivo</i> Studies: Discovery of TDI-11055
Mayako Michino, Tanweer A Khan, Michael W Miller, et al.
ACS Omega
|
January 21, 2020
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
David J Huggins, Bryn S Hardwick, Pooja Sharma, et al.
Biorxiv : the Preprint Server for Biology
|
October 9, 2023
Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes
Jared R Ramsey, Patrick M M Shelton, Tyler K Heiss, et al.
Journal of the American Chemical Society
|
December 22, 2023
Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes
Jared R Ramsey, Patrick M M Shelton, Tyler K Heiss, et al.
ACS Infectious Diseases
|
February 2, 2021
Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions
John Ginn, Xiuju Jiang, Shan Sun, et al.
Biorxiv : the Preprint Server for Biology
|
March 17, 2025
A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression
Jill Zimmerman, Brandon F Malone, Efrat Finkin-Groner, et al.
Journal of Medicinal Chemistry
|
September 5, 2025
Discovery, Optimization, and Evaluation of Non-Nucleoside SARS-CoV-2 NSP14 Inhibitors
Michael W Miller, Cindy Meyer, Aitor Garzia, et al.
Journal of Medicinal Chemistry
|
November 8, 2022
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates
Michael Miller, Thomas Rossetti, Jacob Ferreira, et al.
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Showing results (51-60 of 65) with videos related to
Sort By:
Page
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ACS Medicinal Chemistry Letters
|
March 18, 2022
A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors
Rui Liang, Daisuke Tomita, Yusuke Sasaki, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 23, 2019
Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells
Edouard Mullarky, Jiayi Xu, Anita D Robin, et al.
ACS Medicinal Chemistry Letters
|
April 17, 2024
Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable <i>In Vivo</i> Studies: Discovery of TDI-11055
Mayako Michino, Tanweer A Khan, Michael W Miller, et al.
ACS Omega
|
January 21, 2020
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
David J Huggins, Bryn S Hardwick, Pooja Sharma, et al.
Biorxiv : the Preprint Server for Biology
|
October 9, 2023
Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes
Jared R Ramsey, Patrick M M Shelton, Tyler K Heiss, et al.
Journal of the American Chemical Society
|
December 22, 2023
Using a Function-First "Scout Fragment"-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes
Jared R Ramsey, Patrick M M Shelton, Tyler K Heiss, et al.
ACS Infectious Diseases
|
February 2, 2021
Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions
John Ginn, Xiuju Jiang, Shan Sun, et al.
Biorxiv : the Preprint Server for Biology
|
March 17, 2025
A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression
Jill Zimmerman, Brandon F Malone, Efrat Finkin-Groner, et al.
Journal of Medicinal Chemistry
|
September 5, 2025
Discovery, Optimization, and Evaluation of Non-Nucleoside SARS-CoV-2 NSP14 Inhibitors
Michael W Miller, Cindy Meyer, Aitor Garzia, et al.
Journal of Medicinal Chemistry
|
November 8, 2022
Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates
Michael Miller, Thomas Rossetti, Jacob Ferreira, et al.
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