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Cell Chemical Biology|July 19, 2016
Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse CompoundsJohn R Horton, Xu Liu, Molly Gale, et al.Plos Biology|August 7, 2018
KDM5 histone demethylases repress immune response via suppression of STINGLizhen Wu, Jian Cao, Wesley L Cai, et al.Bioorganic & Medicinal Chemistry Letters|March 27, 2021
Optimization of ether and aniline based inhibitors of lactate dehydrogenasePlamen P Christov, Kwangho Kim, Somnath Jana, et al.Cancer Cell|November 26, 2018
KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic ResistanceKunihiko Hinohara, Hua-Jun Wu, Sébastien Vigneau, et al.Proceedings of the National Academy of Sciences of the United States of America|January 29, 2014
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cellsLesley A Mathews Griner, Rajarshi Guha, Paul Shinn, et al.Scientific Reports|January 23, 2021
Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasitesDorjbal Dorjsuren, Richard T Eastman, Kathryn J Wicht, et al.Journal of Medicinal Chemistry|November 10, 2017
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)Ganesha Rai, Kyle R Brimacombe, Bryan T Mott, et al.Nature Genetics|June 2, 2025
KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavageZheqi Li, Guillermo Peluffo, Laura E Stevens, et al.Cell Reports|February 13, 2020
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination TherapyNobu Oshima, Ryo Ishida, Shun Kishimoto, et al.Journal of Medicinal Chemistry|September 9, 2020
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic PropertiesGanesha Rai, Daniel J Urban, Bryan T Mott, et al.Pageof 11