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Bioorganic & Medicinal Chemistry|February 23, 2016
A potent and selective inhibitor targeting human and murine 12/15-LOXMichelle M Armstrong, Cody J Freedman, Joo Eun Jung, et al.Diabetologia|November 24, 2014
Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunctionDavid A Taylor-Fishwick, Jessica Weaver, Lindsey Glenn, et al.Journal of Medicinal Chemistry|January 24, 2014
4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growthTimothy L Foley, Ganesha Rai, Adam Yasgar, et al.Bioorganic & Medicinal Chemistry Letters|October 20, 2009
Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)Bryan T Mott, Cordelle Tanega, Min Shen, et al.Biochemical and Biophysical Research Communications|December 31, 2021
CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemiaNatsuki Imayoshi, Makoto Yoshioka, Kuniaki Tanaka, et al.Proceedings of the National Academy of Sciences of the United States of America|March 3, 2010
Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124Douglas S Auld, Scott Lovell, Natasha Thorne, et al.Elife|November 28, 2018
Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterolKelly A Manthei, Shyh-Ming Yang, Bolormaa Baljinnyam, et al.Journal of Medicinal Chemistry|September 18, 2014
Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancerThomas S Dexheimer, Andrew S Rosenthal, Diane K Luci, et al.Bioorganic & Medicinal Chemistry Letters|October 1, 2018
Discovery and lead identification of quinazoline-based BRD4 inhibitorsShyh-Ming Yang, Daniel J Urban, Makoto Yoshioka, et al.Retrovirology|December 11, 2012
A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutantsBarry C Johnson, Gary T Pauly, Ganesha Rai, et al.Pageof 11