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Structure (London, England : 1993)|November 15, 2011
Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysisBenjamin Pluvinage, Melanie A Higgins, D Wade Abbott, et al.
Plos One|April 27, 2012
Differential effects of an O-GlcNAcase inhibitor on tau phosphorylationYang Yu, Lan Zhang, Xiaojing Li, et al.
The Journal of Biological Chemistry|June 14, 2012
Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of β-O-linked β-N-acetylglucosaminidaseMatthew S Macauley, Jefferson Chan, Wesley F Zandberg, et al.
Nature Chemical Biology|July 1, 2008
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivoScott A Yuzwa, Matthew S Macauley, Julia E Heinonen, et al.
Angewandte Chemie (International Ed. in English)|June 24, 2014
Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2Erandi Lira-Navarrete, Javier Iglesias-Fernández, Wesley F Zandberg, et al.
Angewandte Chemie (International Ed. in English)|July 21, 2022
Pharmacological Chaperones for GCase that Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal ModelsAndrés G Santana, Kyle Robinson, Chelsea Vickers, et al.
Chemistry (Weinheim an Der Bergstrasse, Germany)|May 22, 2023
Potent and Selective Cell-Active Iminosugar Inhibitors of Human α-N-Acetylgalactosaminidase (α-NAGAL)Roger A Ashmus, Yang Wang, Manuel González-Cuesta, et al.
Biorxiv : the Preprint Server for Biology|May 7, 2024
Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's diseaseDarian Williams, Logan M Glasstetter, Tiffany T Jong, et al.
ACS Catalysis|October 10, 2024
Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent IntermediatesSandeep Bhosale, Sachin Kandalkar, Pierre-André Gilormini, et al.
Chembiochem : a European Journal of Chemical Biology|December 1, 2022
Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of α-Iduronidase, β-Glucuronidase and HeparanaseGareth G Doherty, Geraldine Jia Ming Ler, Norbert Wimmer, et al.
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