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Proceedings of the National Academy of Sciences of the United States of America|October 10, 2024
High-throughput screening for small-molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's diseaseDarian Williams, Logan M Glasstetter, Tiffany T Jong, et al.NPJ Parkinson'S Disease|October 22, 2024
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2Kathi Ging, Lukas Frick, Johannes Schlachetzki, et al.Proceedings of the National Academy of Sciences of the United States of America|June 25, 2024
A metabolic inhibitor blocks cellular fucosylation and enables production of afucosylated antibodiesPierre-André Gilormini, V Narasimharao Thota, Anthony Fers-Lidou, et al.ACS Central Science|October 27, 2025
Enzyme Activity-Based Genome-wide Screening for Modifiers of Lysosomal Glucocerebrosidase Uncovers Candidate Risk Factors for Parkinson's DiseaseVinod Udayar, Pierre-André Gilormini, Julien Bryois, et al.Journal of Medicinal Chemistry|September 6, 2019
Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for TauopathiesHarold G Selnick, J Fred Hess, Cuyue Tang, et al.Acta Crystallographica. Section D, Structural Biology|February 28, 2025
Expansion of the diversity of dispersin scaffoldsAlexandra Males, Olga V Moroz, Elena Blagova, et al.Nature Communications|April 12, 2023
Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle constructAlexandra Gehrlein, Vinod Udayar, Nadia Anastasi, et al.Molecular Neurodegeneration|May 20, 2017
Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 miceNicholas B Hastings, Xiaohai Wang, Lixin Song, et al.The Journal of Pharmacology and Experimental Therapeutics|June 5, 2020
MK-8719, a Novel and Selective <i>O</i>-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of TauopathyXiaohai Wang, Wenping Li, Jacob Marcus, et al.Molecular Neurodegeneration|August 7, 2025
LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosomeMichael T Maloney, Xiang Wang, Rajarshi Ghosh, et al.Pageof 18