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The Journal of Biological Chemistry|February 23, 2013
Characterization of proprotein convertase subtilisin/kexin type 9 (PCSK9) trafficking reveals a novel lysosomal targeting mechanism via amyloid precursor-like protein 2 (APLP2)Rachel M DeVay, David L Shelton, Hong Liang
Plos One|April 24, 2015
Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate Multiple Routes for Internalization and FunctionRachel M DeVay, Lynn Yamamoto, David L Shelton, et al.
Pain|June 2, 2005
Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritisDavid L Shelton, Jörg Zeller, Wei-Hsien Ho, et al.
Anesthesiology|May 24, 2011
Antagonism of nerve growth factor-TrkA signaling and the relief of painPatrick W Mantyh, Martin Koltzenburg, Lorne M Mendell, et al.
Trends in Pharmacological Sciences|December 27, 2005
Novel class of pain drugs based on antagonism of NGFFranz F Hefti, Arnon Rosenthal, Patricia A Walicke, et al.
Bioconjugate Chemistry|December 24, 2013
Mass spectrometric characterization of transglutaminase based site-specific antibody-drug conjugatesSantiago E Farias, Pavel Strop, Kathy Delaria, et al.
The New England Journal of Medicine|October 15, 2010
Tanezumab for the treatment of pain from osteoarthritis of the kneeNancy E Lane, Thomas J Schnitzer, Charles A Birbara, et al.
Pain Reports|June 21, 2018
First-in-human randomized clinical trials of the safety and efficacy of tanezumab for treatment of chronic knee osteoarthritis pain or acute bunionectomy painPatricia A Walicke, Franz Hefti, Roxanne Bales, et al.
Mabs|May 17, 2014
Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexesSherry L La Porte, Charles Eigenbrot, Mark Ultsch, et al.
Toxicologic Pathology|May 18, 2018
Effects of Monoclonal Antibodies against Nerve Growth Factor on Healthy Bone and Joint Tissues in Mice, Rats, and Monkeys: Histopathologic, Biomarker, and Microcomputed Tomographic AssessmentsKathryn E Gropp, Cathy S Carlson, Mark G Evans, et al.
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