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Medchemcomm|October 1, 2013
Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions†Electronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and intermediates. Details for the biological evaluation. Further details for the modeling. Table of combustion analysis data. See DOI: 10.1039/c3md00161jClick here for additional data fileTim J Blackburn, Shafiq Ahmed, Christopher R Coxon, et al.Cell Cycle (Georgetown, Tex.)|December 11, 2008
Transient treatment with CDK inhibitors eliminates proliferative potential even when their abilities to evoke apoptosis and DNA damage are blockedSimon F Scrace, Peter Kierstan, Jenifer Borgognoni, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|July 12, 2003
Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studiesChristopher R Calabrese, Michael A Batey, Huw D Thomas, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|May 4, 2005
Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1E Ruth Plummer, Mark R Middleton, Christopher Jones, et al.Journal of Medicinal Chemistry|January 10, 2003
Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitorsDonald J Skalitzky, Joseph T Marakovits, Karen A Maegley, et al.RSC Medicinal Chemistry|January 22, 2021
2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinaseChristopher J Matheson, Christopher R Coxon, Richard Bayliss, et al.Journal of Medicinal Chemistry|December 6, 2013
8-Substituted O(6)-cyclohexylmethylguanine CDK2 inhibitors: using structure-based inhibitor design to optimize an alternative binding modeBenoit Carbain, David J Paterson, Elizabeth Anscombe, et al.Oncotarget|November 12, 2016
Structure-guided design of purine-based probes for selective Nek2 inhibitionChristopher R Coxon, Christopher Wong, Richard Bayliss, et al.Nature Medicine|June 28, 2011
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibitionNeil Johnson, Yu-Chen Li, Zandra E Walton, et al.Journal of Medicinal Chemistry|July 17, 2013
1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activityCéline Cano, Kappusamy Saravanan, Chris Bailey, et al.Pageof 8