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Nature Structural Biology|September 24, 2002
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitorThomas G Davies, Johanne Bentley, Christine E Arris, et al.Journal of Medicinal Chemistry|July 9, 2004
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2Ian R Hardcastle, Christine E Arris, Johanne Bentley, et al.Bioorganic & Medicinal Chemistry Letters|February 17, 2005
Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interactionIan R Hardcastle, Shafiq U Ahmed, Helen Atkins, et al.Journal of Medicinal Chemistry|March 21, 2007
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinaseJonathan J Hollick, Laurent J M Rigoreau, Celine Cano-Soumillac, et al.Journal of the National Cancer Institute|January 8, 2004
Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361Christopher R Calabrese, Robert Almassy, Stephanie Barton, et al.Journal of Medicinal Chemistry|October 16, 2004
Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymeraseJayashree G Tikhe, Stephen E Webber, Zdenek Hostomsky, et al.The Journal of Clinical Investigation|October 4, 2019
Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapyCatherine E Willoughby, Yanyan Jiang, Huw D Thomas, et al.Journal of Medicinal Chemistry|December 23, 2016
Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-ArylaminopurinesChristopher R Coxon, Elizabeth Anscombe, Suzannah J Harnor, et al.Journal of Medicinal Chemistry|February 15, 2011
Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potencyIan R Hardcastle, Junfeng Liu, Eric Valeur, et al.Journal of Medicinal Chemistry|November 1, 2002
Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structureStacie S Canan Koch, Lars H Thoresen, Jayashree G Tikhe, et al.Pageof 8