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Drug Delivery and Translational Research|April 30, 2026
Translatability of a miniature pig model to predict subcutaneous clinical injection times with a high-volume auto-injector and recombinant human hyaluronidaseRobert J Connor, Tara Nekoroski, David W Kang
AAPS Pharmscitech|May 16, 2025
Development and Preclinical Testing of a Rapid, High-Volume, Auto-Injector for Subcutaneous Administration with Recombinant Human HyaluronidaseRobert J Connor, Tara Nekoroski, David W Kang
Drug Delivery|September 13, 2023
Identifying a predictive relationship between maximal flow rate and viscosity for subcutaneous administration of macromolecules with recombinant human hyaluronidase PH20 in a miniature pig modelRobert J Connor, Renee Clift, David W Kang
AAPS Pharmscitech|January 7, 2021
Subcutaneous Injection Performance in Yucatan Miniature Pigs with and without Human Hyaluronidase and Auto-injector Tolerability in HumansGalen H Shi, Robert J Connor, David S Collins, et al.
Drug Delivery and Translational Research|March 20, 2015
Recombinant human hyaluronidase PH20 (rHuPH20) facilitates subcutaneous infusions of large volumes of immunoglobulin in a swine modelDavid W Kang, Laurence Jadin, Tara Nekoroski, et al.
Biophysical Journal|June 21, 2018
Single-Molecule Unbinding Forces between the Polysaccharide Hyaluronan and Its Binding ProteinsFouzia Bano, Markku I Tammi, David W Kang, et al.
Dermatology and Therapy|May 4, 2020
A Preclinical Investigation into the Effects of Aging on Dermal Hyaluronan Properties and Reconstitution Following Recombinant Human Hyaluronidase PH20 AdministrationRobert J Connor, Barbara Blouw, Jessica Cowell, et al.
Plos One|July 22, 2021
Dispersive effects and focused biodistribution of recombinant human hyaluronidase PH20: A locally acting and transiently active permeation enhancerDavid W Kang, Beate Bittner, Barry J Sugarman, et al.
Pharmaceutical Research|July 1, 2022
Mechanistic Modeling of the Effect of Recombinant Human Hyaluronidase (rHuPH20) on Subcutaneous Delivery of Cetuximab in RatsXizhe Gao, Jongbong Lee, Kiran Deshpande, et al.
Journal of Pharmacological and Toxicological Methods|November 16, 2020
Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine modelRobert J Connor, Darin M Taverna, Karla Thrall, et al.
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