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The Journal of Organic Chemistry
|
July 8, 2015
Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development
Scott A Shaw, Balu Balasubramanian, Samuel Bonacorsi, et al.
Journal of Medicinal Chemistry
|
September 8, 2021
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy
Andrew K Dilger, Kumar B Pabbisetty, James R Corte, et al.
ACS Medicinal Chemistry Letters
|
May 31, 2021
Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis
Qingjie Liu, Hai-Yun Xiao, Douglas G Batt, et al.
Bioorganic & Medicinal Chemistry Letters
|
February 12, 2014
Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent
Yoon T Jeon, Wu Yang, Jennifer X Qiao, et al.
ACS Medicinal Chemistry Letters
|
November 20, 2020
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK
Anurag S Srivastava, Soo Ko, Scott H Watterson, et al.
Journal of Medicinal Chemistry
|
September 20, 2021
Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design
Ashvinikumar V Gavai, Derek Norris, George Delucca, et al.
Journal of Medicinal Chemistry
|
September 2, 2016
Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers
Scott H Watterson, George V De Lucca, Qing Shi, et al.
Journal of Medicinal Chemistry
|
March 8, 2022
Discovery of (<i>S</i>)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain
Guanglin Luo, Ling Chen, Walter A Kostich, et al.
Journal of Medicinal Chemistry
|
February 18, 2022
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1<i>H</i>-pyrazol-1-yl)methyl)phosphonate (BMS-820132)
Yan Shi, Ying Wang, Wei Meng, et al.
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of 2
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Showing results (11-20 of 19) with videos related to
Sort By:
Page
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You have reached the last page of results.
This site can display upto 19 results.
The Journal of Organic Chemistry
|
July 8, 2015
Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development
Scott A Shaw, Balu Balasubramanian, Samuel Bonacorsi, et al.
Journal of Medicinal Chemistry
|
September 8, 2021
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy
Andrew K Dilger, Kumar B Pabbisetty, James R Corte, et al.
ACS Medicinal Chemistry Letters
|
May 31, 2021
Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis
Qingjie Liu, Hai-Yun Xiao, Douglas G Batt, et al.
Bioorganic & Medicinal Chemistry Letters
|
February 12, 2014
Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent
Yoon T Jeon, Wu Yang, Jennifer X Qiao, et al.
ACS Medicinal Chemistry Letters
|
November 20, 2020
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK
Anurag S Srivastava, Soo Ko, Scott H Watterson, et al.
Journal of Medicinal Chemistry
|
September 20, 2021
Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design
Ashvinikumar V Gavai, Derek Norris, George Delucca, et al.
Journal of Medicinal Chemistry
|
September 2, 2016
Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers
Scott H Watterson, George V De Lucca, Qing Shi, et al.
Journal of Medicinal Chemistry
|
March 8, 2022
Discovery of (<i>S</i>)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain
Guanglin Luo, Ling Chen, Walter A Kostich, et al.
Journal of Medicinal Chemistry
|
February 18, 2022
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1<i>H</i>-pyrazol-1-yl)methyl)phosphonate (BMS-820132)
Yan Shi, Ying Wang, Wei Meng, et al.
Page
of 2