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Chemical Research in Toxicology
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January 17, 2009
Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites
Deepak Dalvie, R Scott Obach, Ping Kang, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
September 18, 2021
Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5
Julie V Selkirk, Kevin C Dines, Yingzhuo Grace Yan, et al.
Bioorganic & Medicinal Chemistry Letters
|
March 20, 2013
Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series
Hengmiao Cheng, Jacqui E Hoffman, Phuong T Le, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
March 6, 2021
Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator
Sekhar Surapaneni, Usha Yerramilli, April Bai, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
December 19, 2013
Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance
Phillip A Schwartz, Petr Kuzmic, James Solowiej, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 4, 2012
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR
Phuong T Le, Hengmiao Cheng, Sacha Ninkovic, et al.
Drug Metabolism Reviews
|
May 13, 2026
Identification and characterization of a novel aldehyde metabolite of WIN18,446 and associated WIN18,446-ALDH1A2 protein adducts using mass spectrometry
Alex Zelter, Guo Zhong, Michal Maes, et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
|
July 19, 2014
Metabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects
Theodore R Johnson, Weiwei Tan, Lance Goulet, et al.
Journal of Medicinal Chemistry
|
August 16, 2022
Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections
Natalie Hawryluk, Dale Robinson, Yixing Shen, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 2, 2010
Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK
Steven P Tanis, Michael B Plewe, Ted W Johnson, et al.
Page
of 5
Search research articles
Search
Showing results (31-40 of 49) with videos related to
Sort By:
Page
of 5
Chemical Research in Toxicology
|
January 17, 2009
Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites
Deepak Dalvie, R Scott Obach, Ping Kang, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
September 18, 2021
Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine 1-Phosphate Receptor Subtypes 1 and 5
Julie V Selkirk, Kevin C Dines, Yingzhuo Grace Yan, et al.
Bioorganic & Medicinal Chemistry Letters
|
March 20, 2013
Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series
Hengmiao Cheng, Jacqui E Hoffman, Phuong T Le, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
March 6, 2021
Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator
Sekhar Surapaneni, Usha Yerramilli, April Bai, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
December 19, 2013
Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance
Phillip A Schwartz, Petr Kuzmic, James Solowiej, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 4, 2012
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR
Phuong T Le, Hengmiao Cheng, Sacha Ninkovic, et al.
Drug Metabolism Reviews
|
May 13, 2026
Identification and characterization of a novel aldehyde metabolite of WIN18,446 and associated WIN18,446-ALDH1A2 protein adducts using mass spectrometry
Alex Zelter, Guo Zhong, Michal Maes, et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
|
July 19, 2014
Metabolism, excretion and pharmacokinetics of [14C]crizotinib following oral administration to healthy subjects
Theodore R Johnson, Weiwei Tan, Lance Goulet, et al.
Journal of Medicinal Chemistry
|
August 16, 2022
Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections
Natalie Hawryluk, Dale Robinson, Yixing Shen, et al.
Bioorganic & Medicinal Chemistry Letters
|
November 2, 2010
Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK
Steven P Tanis, Michael B Plewe, Ted W Johnson, et al.
Page
of 5