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Dennis Colussi

Showing results (21-30 of 27) with videos related to

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Biochemistry|March 17, 2009
Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tetheringWenjin Yang, Raymond V Fucini, Bruce T Fahr, et al.
Bioorganic & Medicinal Chemistry Letters|May 8, 2007
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitorsStacey R Lindsley, Keith P Moore, Hemaka A Rajapakse, et al.
Bioorganic & Medicinal Chemistry Letters|February 24, 2010
SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibitionHemaka A Rajapakse, Philippe G Nantermet, Harold G Selnick, et al.
Journal of Medicinal Chemistry|September 25, 2008
Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretaseJames C Barrow, Shaun R Stauffer, Kenneth E Rittle, et al.
Proceedings of the National Academy of Sciences of the United States of America|November 14, 2006
LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's diseaseJohn Majercak, William J Ray, Amy Espeseth, et al.
Bioorganic & Medicinal Chemistry Letters|July 22, 2015
Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potencyMelissa Egbertson, Georgia B McGaughey, Steven M Pitzenberger, et al.
The Journal of Pharmacology and Experimental Therapeutics|October 16, 2008
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primatesSethu Sankaranarayanan, Marie A Holahan, Dennis Colussi, et al.
Pageof 3

Showing results (21-30 of 27) with videos related to

Sort By:
Pageof 3
You have reached the last page of results.This site can display upto 27 results.
Biochemistry|March 17, 2009
Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tetheringWenjin Yang, Raymond V Fucini, Bruce T Fahr, et al.
Bioorganic & Medicinal Chemistry Letters|May 8, 2007
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitorsStacey R Lindsley, Keith P Moore, Hemaka A Rajapakse, et al.
Bioorganic & Medicinal Chemistry Letters|February 24, 2010
SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibitionHemaka A Rajapakse, Philippe G Nantermet, Harold G Selnick, et al.
Journal of Medicinal Chemistry|September 25, 2008
Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretaseJames C Barrow, Shaun R Stauffer, Kenneth E Rittle, et al.
Proceedings of the National Academy of Sciences of the United States of America|November 14, 2006
LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's diseaseJohn Majercak, William J Ray, Amy Espeseth, et al.
Bioorganic & Medicinal Chemistry Letters|July 22, 2015
Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potencyMelissa Egbertson, Georgia B McGaughey, Steven M Pitzenberger, et al.
The Journal of Pharmacology and Experimental Therapeutics|October 16, 2008
First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primatesSethu Sankaranarayanan, Marie A Holahan, Dennis Colussi, et al.
Pageof 3