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Journal of Medicinal Chemistry|October 24, 2007
Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonistDerek C Cole, Joseph R Stock, William J Lennox, et al.Bioorganic & Medicinal Chemistry Letters|December 11, 2007
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocketLee D Jennings, Derek C Cole, Joseph R Stock, et al.Bioorganic & Medicinal Chemistry Letters|December 29, 2007
Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pocketsDerek C Cole, Joseph R Stock, Rajiv Chopra, et al.Bioorganic & Medicinal Chemistry Letters|December 5, 2009
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitorsPawel Nowak, Derek C Cole, Ann Aulabaugh, et al.Journal of Medicinal Chemistry|October 13, 2006
Acylguanidines as small-molecule beta-secretase inhibitorsDerek C Cole, Eric S Manas, Joseph R Stock, et al.Bioorganic & Medicinal Chemistry Letters|June 17, 2008
Discovery of a novel series of Notch-sparing gamma-secretase inhibitorsAnthony Kreft, Boyd Harrison, Suzan Aschmies, et al.Bioorganic & Medicinal Chemistry Letters|December 23, 2008
(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitorDerek C Cole, Joseph R Stock, Anthony F Kreft, et al.Journal of Medicinal Chemistry|November 18, 2008
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's diseaseScott C Mayer, Anthony F Kreft, Boyd Harrison, et al.Pageof 3