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Journal of Medicinal Chemistry|December 4, 2003
A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055Diane E Gingrich, Dandu R Reddy, Mohamed A Iqbal, et al.Journal of Medicinal Chemistry|December 14, 2011
Synthesis and biological profile of the pan-vascular endothelial growth factor receptor/tyrosine kinase with immunoglobulin and epidermal growth factor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): a novel oncology therapeutic agentRobert L Hudkins, Nadine C Becknell, Allison L Zulli, et al.Blood|October 29, 2005
Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cellsWeihua Wan, Mark S Albom, Lihui Lu, et al.Bioorganic & Medicinal Chemistry Letters|February 7, 2015
Piperidine-3,4-diol and piperidine-3-ol derivatives of pyrrolo[2,1-f][1,2,4]triazine as inhibitors of anaplastic lymphoma kinaseEugen F Mesaros, Thelma S Angeles, Mark S Albom, et al.Animal Microbiome|November 6, 2024
The role of gut microbiota in a generalist, golden snub-nosed monkey, adaptation to geographical diet changeYuhang Li, Yujie Yan, Haojie Wu, et al.Bioorganic & Medicinal Chemistry Letters|November 16, 2010
Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse modelsEugen F Mesaros, Jason P Burke, Jonathan D Parrish, et al.Journal of Medicinal Chemistry|May 9, 2012
Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinaseDiane E Gingrich, Joseph G Lisko, Matthew A Curry, et al.Bioorganic & Medicinal Chemistry Letters|December 7, 2011
4,5-dihydropyridazin-3-one derivatives as histamine H₃ receptor inverse agonistsRobert L Hudkins, Lisa D Aimone, Reddeppa Reddy Dandu, et al.The Lancet. Respiratory Medicine|March 23, 2023
Intravenous ravulizumab in mechanically ventilated patients hospitalised with severe COVID-19: a phase 3, multicentre, open-label, randomised controlled trialDjillali Annane, Sean J Pittock, Hrishikesh S Kulkarni, et al.Journal of Medicinal Chemistry|August 24, 2011
2,7-disubstituted-pyrrolo[2,1-f][1,2,4]triazines: new variant of an old template and application to the discovery of anaplastic lymphoma kinase (ALK) inhibitors with in vivo antitumor activityGregory R Ott, Gregory J Wells, Tho V Thieu, et al.Pageof 14