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Journal of Medicinal Chemistry|May 19, 2012
A selective, orally bioavailable 1,2,4-triazolo[1,5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779Benjamin J Dugan, Diane E Gingrich, Eugen F Mesaros, et al.Bioorganic & Medicinal Chemistry Letters|August 3, 2011
4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitorsMark W Holladay, Brian T Campbell, Martin W Rowbottom, et al.JCI Insight|November 3, 2017
Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatmentAmar N Mirza, Micah A Fry, Nicole M Urman, et al.Molecular Cancer Therapeutics|February 10, 2012
CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activityJoyce James, Bruce Ruggeri, Robert C Armstrong, et al.Bioorganic & Medicinal Chemistry Letters|December 16, 2011
Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinasesCraig A Zificsak, Diane E Gingrich, Henry J Breslin, et al.Integrative Zoology|April 15, 2025
An Automated AI Framework for Quantitative Measurement of Mammalian BehaviorJia Liu, Tao Liu, Zhengfeng Hu, et al.Bioorganic & Medicinal Chemistry Letters|December 31, 2010
2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilinesCraig A Zificsak, Jay P Theroff, Lisa D Aimone, et al.Journal of Medicinal Chemistry|December 7, 2011
Strategies to mitigate the bioactivation of 2-anilino-7-aryl-pyrrolo[2,1-f][1,2,4]triazines: identification of orally bioavailable, efficacious ALK inhibitorsEugen F Mesaros, Tho V Thieu, Gregory J Wells, et al.ACS Chemical Neuroscience|March 4, 2022
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand ComplexesAndrew D Cansfield, Mark A Ator, Joydeep Banerjee, et al.Journal of Medicinal Chemistry|August 17, 2016
Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)Gregory R Ott, Mangeng Cheng, Keith S Learn, et al.Pageof 14