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Plos One|December 3, 2015
Combination of a Selective HSP90α/β Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma CellsRikio Suzuki, Shohei Kikuchi, Takeshi Harada, et al.
British Journal of Haematology|March 25, 2010
Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivoKihyun Kim, Sun-Young Kong, Mariateresa Fulciniti, et al.
British Journal of Haematology|April 10, 2008
p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implicationsKenji Ishitsuka, Teru Hideshima, Paola Neri, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|November 26, 2009
Interactions of the Hdm2/p53 and proteasome pathways may enhance the antitumor activity of bortezomibMelissa G Ooi, Patrick J Hayden, Vassiliki Kotoula, et al.
Blood|March 5, 2008
Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemiaAldo M Roccaro, Xavier Leleu, Antonio Sacco, et al.
Blood Cancer Discovery|September 27, 2021
Bortezomib induces anti-multiple myeloma immune response mediated by cGAS/STING pathway activationAnnamaria Gulla, Eugenio Morelli, Mehmet K Samur, et al.
Blood|October 18, 2002
Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myelomaPaul G Richardson, Robert L Schlossman, Edie Weller, et al.
Blood|March 27, 2007
JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cellsTanyel Kiziltepe, Teru Hideshima, Kenji Ishitsuka, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|June 12, 2016
Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation StatusMichele Cea, Antonia Cagnetta, Chirag Acharya, et al.
Blood|December 18, 2015
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cellsMichele Cea, Antonia Cagnetta, Sophia Adamia, et al.
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