Showing results (11-20 of 39) with videos related to

Sort By:
Pageof 4
Journal of Neurochemistry|November 25, 2005
C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformationJun Wang, Dirk Beher, Andrew C Nyborg, et al.
Chemical Biology & Drug Design|October 22, 2009
Resveratrol is not a direct activator of SIRT1 enzyme activityDirk Beher, John Wu, Suzanne Cumine, et al.
ACS Chemical Neuroscience|March 31, 2022
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein ProteinopathiesBruno Permanne, Astrid Sand, Solenne Ousson, et al.
Proceedings of the National Academy of Sciences of the United States of America|January 24, 2002
The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domainStefan F Lichtenthaler, Dirk Beher, Heike S Grimm, et al.
Journal of Neurochemistry|December 21, 2012
Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacologySolenne Ousson, Arman Saric, Aurelie Baguet, et al.
The Journal of Biological Chemistry|August 12, 2004
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanismDirk Beher, Earl E Clarke, Jonathan D J Wrigley, et al.
The Journal of Biological Chemistry|August 11, 2006
Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classesEarl E Clarke, Ian Churcher, Semantha Ellis, et al.
Journal of Biomolecular Screening|October 2, 2012
Development and characterization of a novel membrane assay for full-length BACE-1 at pH 6.0Arman Saric, Lars zur Brügge, Dirk Müller-Pompalla, et al.
ACS Chemical Biology|June 26, 2012
Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screeningHeiko Zettl, Julia Ness, Volker Hähnke, et al.
Bioorganic & Medicinal Chemistry Letters|May 10, 2006
3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activityRichard A Jelley, Jason Elliott, Karl R Gibson, et al.
Pageof 4