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Nature Reviews. Cancer|October 19, 2007
Carboxypeptidase-G2-based gene-directed enzyme-prodrug therapy: a new weapon in the GDEPT armouryDouglas Hedley, Lesley Ogilvie, Caroline SpringerCancer Research|April 3, 2004
V599EB-RAF is an oncogene in melanocytesClaudia Wellbrock, Lesley Ogilvie, Douglas Hedley, et al.Journal of Medicinal Chemistry|August 5, 2005
Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapyLawrence C Davies, Frank Friedlos, Douglas Hedley, et al.Cancer Research|October 5, 2006
In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signalingNicolas Dumaz, Robert Hayward, Jan Martin, et al.Cancer Research|May 19, 2007
Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2Silke Schepelmann, Lesley M Ogilvie, Douglas Hedley, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|July 3, 2008
Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapyFrank Friedlos, Panos Lehouritis, Lesley Ogilvie, et al.Cancer Research|June 17, 2005
Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2Silke Schepelmann, Paul Hallenbeck, Lesley M Ogilvie, et al.Oncogene|June 23, 2004
B-RAF is a therapeutic target in melanomaMaria Karasarides, Antonio Chiloeches, Robert Hayward, et al.Pigment Cell & Melanoma Research|December 17, 2009
Inducible expression of (V600E) Braf using tyrosinase-driven Cre recombinase results in embryonic lethalityNathalie Dhomen, Silvy Da Rocha Dias, Robert Hayward, et al.Cancer Research|September 3, 2010
A novel, selective, and efficacious nanomolar pyridopyrazinone inhibitor of V600EBRAFSteven Whittaker, Delphine Ménard, Ruth Kirk, et al.Pageof 2