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Drug Metabolism and Disposition: the Biological Fate of Chemicals|March 27, 2023
Human Absorption, Distribution, Metabolism, and Excretion Studies: Origins, Innovations, and ImportanceMatthew A Cerny, Douglas K Spracklin, R Scott ObachCPT: Pharmacometrics & Systems Pharmacology|June 21, 2020
Mini-Review: Comprehensive Drug Disposition Knowledge Generated in the Modern Human Radiolabeled ADME StudyDouglas K Spracklin, Danny Chen, Arthur J Bergman, et al.Journal of Medicinal Chemistry|February 26, 2020
Effective Application of Metabolite Profiling in Drug Design and DiscoveryMatthew A Cerny, Amit S Kalgutkar, R Scott Obach, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 24, 2014
Biosynthesis of drug metabolites and quantitation using NMR spectroscopy for use in pharmacologic and drug metabolism studiesGregory S Walker, Jonathan N Bauman, Tim F Ryder, et al.European Journal of Pharmacology|January 4, 2005
The role of muscarinic receptor antagonism in antipsychotic-induced hippocampal acetylcholine releaseDavid E Johnson, Frank M Nedza, Douglas K Spracklin, et al.Schizophrenia Bulletin|August 16, 2008
Differential effects of various typical and atypical antipsychotics on plasma glucose and insulin levels in the mouse: evidence for the involvement of sympathetic regulationYvette E Savoy, Michael A Ashton, Matthew W Miller, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|December 23, 2011
Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugsRaman Sharma, Timothy J Strelevitz, Hongying Gao, et al.Bioorganic & Medicinal Chemistry Letters|July 7, 2009
Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonistsChristopher J O'Donnell, Langu Peng, Brian T O'Neill, et al.Xenobiotica; the Fate of Foreign Compounds in Biological Systems|June 30, 2016
Quantitative projection of human brain penetration of the H<sub>3</sub> antagonist PF-03654746 by integrating rat-derived brain partitioning and PET receptor occupancyAarti Sawant-Basak, Laigao Chen, Christopher L Shaffer, et al.Drug Metabolism and Disposition: the Biological Fate of Chemicals|March 6, 2025
Cross-industry demonstration of the validity of the mixed matrix method for the assessment of cross-species exposure coverage of human circulating drug metabolitesAlexander D James, Christian Lanshoeft, Gregory S Steeno, et al.Pageof 3