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Dow P Hurst

Showing results (31-40 of 57) with videos related to

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The Journal of Biological Chemistry|May 24, 2014
Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complexJagjeet S Mnpotra, Zhuanhong Qiao, Jian Cai, et al.
European Journal of Medicinal Chemistry|May 31, 2008
Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): development of ligands with optimized lipophilicity and binding affinityHong Fan, Evangelia Kotsikorou, Alexander F Hoffman, et al.
Chemmedchem|March 26, 2018
Synthesis, Pharmacological Evaluation, and Docking Studies of Novel Pyridazinone-Based Cannabinoid Receptor Type 2 LigandsGiulio Ragusa, Serena Bencivenni, Paula Morales, et al.
Cannabis and Cannabinoid Research|July 6, 2022
The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid ReceptorLuciana M Leo, Rufaida Al-Zoubi, Dow P Hurst, et al.
Molecular Pharmacology|November 19, 2002
N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptorDow P Hurst, Diane L Lynch, Judy Barnett-Norris, et al.
Biochemical Pharmacology|July 12, 2002
A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognitionSean D McAllister, Qing Tao, Judy Barnett-Norris, et al.
Molecular Pharmacology|September 15, 2005
(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptorRobert P Picone, Atmaram D Khanolkar, Wei Xu, et al.
Frontiers in Pharmacology|November 17, 2022
Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593Asher L Brandt, Sumanta Garai, Ayat Zagzoog, et al.
Journal of Medicinal Chemistry|July 17, 2013
The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528)Evangelia Kotsikorou, Frank Navas, Michael J Roche, et al.
The Journal of Biological Chemistry|June 28, 2007
Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanismsSharon Anavi-Goffer, Daniel Fleischer, Dow P Hurst, et al.
Pageof 6

Showing results (31-40 of 57) with videos related to

Sort By:
Pageof 6
The Journal of Biological Chemistry|May 24, 2014
Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complexJagjeet S Mnpotra, Zhuanhong Qiao, Jian Cai, et al.
European Journal of Medicinal Chemistry|May 31, 2008
Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): development of ligands with optimized lipophilicity and binding affinityHong Fan, Evangelia Kotsikorou, Alexander F Hoffman, et al.
Chemmedchem|March 26, 2018
Synthesis, Pharmacological Evaluation, and Docking Studies of Novel Pyridazinone-Based Cannabinoid Receptor Type 2 LigandsGiulio Ragusa, Serena Bencivenni, Paula Morales, et al.
Cannabis and Cannabinoid Research|July 6, 2022
The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid ReceptorLuciana M Leo, Rufaida Al-Zoubi, Dow P Hurst, et al.
Molecular Pharmacology|November 19, 2002
N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptorDow P Hurst, Diane L Lynch, Judy Barnett-Norris, et al.
Biochemical Pharmacology|July 12, 2002
A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognitionSean D McAllister, Qing Tao, Judy Barnett-Norris, et al.
Molecular Pharmacology|September 15, 2005
(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptorRobert P Picone, Atmaram D Khanolkar, Wei Xu, et al.
Frontiers in Pharmacology|November 17, 2022
Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593Asher L Brandt, Sumanta Garai, Ayat Zagzoog, et al.
Journal of Medicinal Chemistry|July 17, 2013
The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528)Evangelia Kotsikorou, Frank Navas, Michael J Roche, et al.
The Journal of Biological Chemistry|June 28, 2007
Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanismsSharon Anavi-Goffer, Daniel Fleischer, Dow P Hurst, et al.
Pageof 6