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Cancer Research|September 24, 2009
Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphataseGary K Freschauf, Feridoun Karimi-Busheri, Agnieszka Ulaczyk-Lesanko, et al.
The Journal of Biological Chemistry|January 14, 2026
F2,6BP restores mitochondrial genome integrity in Huntington's DiseaseAnirban Chakraborty, Santi M Mandal, Mikita Mankevich, et al.
The Journal of Biological Chemistry|July 22, 2011
XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repairMichal Hammel, Martial Rey, Yaping Yu, et al.
Frontiers in Oncology|April 4, 2022
Modulation of ERCC1-XPF Heterodimerization Inhibition <i>via</i> Structural Modification of Small Molecule Inhibitor Side-ChainsClaudia Weilbeer, David Jay, James C Donnelly, et al.
Molecular Cell|March 8, 2005
The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinaseNina K Bernstein, R Scott Williams, Melissa L Rakovszky, et al.
Nucleic Acids Research|August 10, 2011
Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damageAngela E Zolner, Ismail Abdou, Ruiqiong Ye, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society|May 2, 2021
A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3'-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancerSams M A Sadat, Igor M Paiva, Zahra Shire, et al.
Cell Reports|December 13, 2024
PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stressFatemeh Mashayekhi, Cassandra Ganje, Marie-Christine Caron, et al.
Redox Biology|April 17, 2022
Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agentsFaisal Bin Rashed, Diana Diaz-Dussan, Fatemeh Mashayekhi, et al.
Cancer Research|May 13, 2010
Pathways of proliferation and antiapoptosis driven in breast cancer stem cells by stem cell protein piwil2Jae Ho Lee, Cornelia Jung, Parisa Javadian-Elyaderani, et al.
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