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Journal of Clinical Pharmacology|March 22, 2021
Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its MetabolitesEllen Q Wang, Vu Le, Melissa O'Gorman, et al.
British Journal of Clinical Pharmacology|May 7, 2025
Drug-drug interaction profile of ritlecitinib as perpetrator and victim through cytochrome P450Vivek S Purohit, Yeamin Huh, Martin E Dowty, et al.
The Journal of Pharmacology and Experimental Therapeutics|November 13, 2013
Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritisMartin E Dowty, Michael I Jesson, Sarbani Ghosh, et al.
British Journal of Clinical Pharmacology|May 15, 2023
A phase 1 study to investigate the absorption, distribution, metabolism and excretion of brepocitinib in healthy males using a 14 C-microdose approachRuolun Qiu, Raman Sharma, Hua Wei, et al.
Pharmacology Research & Perspectives|December 14, 2019
Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibitionMartin E Dowty, Tsung H Lin, Michael I Jesson, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|May 8, 2024
The Metabolism and Disposition of Brepocitinib in Humans and Characterization of the Formation Mechanism of an Aminopyridine MetaboliteMartin E Dowty, Ruolun Qiu, Alyssa Dantonio, et al.
Clinical Pharmacology in Drug Development|April 30, 2016
Evaluation of the potential interaction between tofacitinib and drugs that undergo renal tubular secretion using metformin, an in vivo marker of renal organic cation transporter 2Karen J Klamerus, Christine Alvey, Lei Li, et al.
British Journal of Clinical Pharmacology|January 12, 2012
Lack of effect of tofacitinib (CP-690,550) on the pharmacokinetics of the CYP3A4 substrate midazolam in healthy volunteers: confirmation of in vitro dataPankaj Gupta, Christine Alvey, Rong Wang, et al.
Journal of Clinical Pharmacology|October 12, 2021
Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its MetabolitesEllen Q Wang, Vu Le, Jennifer A Winton, et al.
Journal of Cell Science|December 1, 1992
Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscleJ A Wolff, M E Dowty, S Jiao, et al.
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