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Cancer Research
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February 11, 2010
MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor
Bo-Sheng Pan, Grace K Y Chan, Melissa Chenard, et al.
British Journal of Pharmacology
|
September 25, 2009
Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia
J Tammam, C Ware, C Efferson, et al.
Journal of Medicinal Chemistry
|
March 29, 1996
2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase
T M Williams, T M Ciccarone, S C MacTough, et al.
Bioorganic & Medicinal Chemistry Letters
|
September 1, 2007
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP
Paul J Coleman, John D Schreier, Christopher D Cox, et al.
Cancer Discovery
|
December 13, 2022
NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations
Alexander Drilon, Joshua C Horan, Anupong Tangpeerachaikul, et al.
Journal of Medicinal Chemistry
|
October 13, 2021
Discovery of 6-[(3<i>S</i>,4<i>S</i>)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor
Barbara Czako, Yuting Sun, Timothy McAfoos, et al.
Bioorganic & Medicinal Chemistry Letters
|
January 28, 2006
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility
Robert M Garbaccio, Mark E Fraley, Edward S Tasber, et al.
Journal of Medicinal Chemistry
|
October 3, 1999
N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity
T M Williams, J M Bergman, K Brashear, et al.
Cancer Research
|
May 29, 2000
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor
C A Omer, Z Chen, R E Diehl, et al.
Nature
|
September 30, 2015
Mediator kinase inhibition further activates super-enhancer-associated genes in AML
Henry E Pelish, Brian B Liau, Ioana I Nitulescu, et al.
Page
of 13
Search research articles
Search
Showing results (111-120 of 129) with videos related to
Sort By:
Page
of 13
Cancer Research
|
February 11, 2010
MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor
Bo-Sheng Pan, Grace K Y Chan, Melissa Chenard, et al.
British Journal of Pharmacology
|
September 25, 2009
Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia
J Tammam, C Ware, C Efferson, et al.
Journal of Medicinal Chemistry
|
March 29, 1996
2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase
T M Williams, T M Ciccarone, S C MacTough, et al.
Bioorganic & Medicinal Chemistry Letters
|
September 1, 2007
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP
Paul J Coleman, John D Schreier, Christopher D Cox, et al.
Cancer Discovery
|
December 13, 2022
NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations
Alexander Drilon, Joshua C Horan, Anupong Tangpeerachaikul, et al.
Journal of Medicinal Chemistry
|
October 13, 2021
Discovery of 6-[(3<i>S</i>,4<i>S</i>)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor
Barbara Czako, Yuting Sun, Timothy McAfoos, et al.
Bioorganic & Medicinal Chemistry Letters
|
January 28, 2006
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility
Robert M Garbaccio, Mark E Fraley, Edward S Tasber, et al.
Journal of Medicinal Chemistry
|
October 3, 1999
N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity
T M Williams, J M Bergman, K Brashear, et al.
Cancer Research
|
May 29, 2000
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor
C A Omer, Z Chen, R E Diehl, et al.
Nature
|
September 30, 2015
Mediator kinase inhibition further activates super-enhancer-associated genes in AML
Henry E Pelish, Brian B Liau, Ioana I Nitulescu, et al.
Page
of 13