Search research articles
Contact Us
Filters
Showing results (41-50 of 56) with videos related to
Page
of 6
Sort By:
Bioorganic & Medicinal Chemistry Letters
|
May 19, 2019
Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists
Jérôme Amaudrut, Maria A Argiriadi, Martine Barth, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
May 10, 2012
Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature
Regina M Reilly, Heath A McDonald, Pamela S Puttfarcken, et al.
Journal of Medicinal Chemistry
|
March 7, 2003
Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines
Philip R Kym, Michael E Kort, Michael J Coghlan, et al.
Pain
|
March 16, 2011
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
Jun Chen, Shailen K Joshi, Stanley DiDomenico, et al.
Bioorganic & Medicinal Chemistry
|
April 18, 2022
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na<sub>v</sub>1.7/ Nav1.8 blockers for the treatment of pain
Meena V Patel, Hillary M Peltier, Mark A Matulenko, et al.
Bioorganic & Medicinal Chemistry
|
October 23, 2010
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain
Marc J C Scanio, Lei Shi, Irene Drizin, et al.
Journal of Medicinal Chemistry
|
May 28, 2004
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions
William A Carroll, Robert J Altenbach, Hao Bai, et al.
Communications Chemistry
|
August 16, 2024
Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex
Qi Hao, Manoj K Rathinaswamy, Kelly L Klinge, et al.
Pain
|
January 13, 2009
Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia
Prisca Honore, Prasant Chandran, Gricelda Hernandez, et al.
Journal of Medicinal Chemistry
|
March 6, 2023
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis <i>In Vivo</i>
John T Randolph, Matthew J O'Connor, Fei Han, et al.
Page
of 6
Search research articles
Search
Showing results (41-50 of 56) with videos related to
Sort By:
Page
of 6
Bioorganic & Medicinal Chemistry Letters
|
May 19, 2019
Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists
Jérôme Amaudrut, Maria A Argiriadi, Martine Barth, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
May 10, 2012
Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature
Regina M Reilly, Heath A McDonald, Pamela S Puttfarcken, et al.
Journal of Medicinal Chemistry
|
March 7, 2003
Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines
Philip R Kym, Michael E Kort, Michael J Coghlan, et al.
Pain
|
March 16, 2011
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
Jun Chen, Shailen K Joshi, Stanley DiDomenico, et al.
Bioorganic & Medicinal Chemistry
|
April 18, 2022
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na<sub>v</sub>1.7/ Nav1.8 blockers for the treatment of pain
Meena V Patel, Hillary M Peltier, Mark A Matulenko, et al.
Bioorganic & Medicinal Chemistry
|
October 23, 2010
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain
Marc J C Scanio, Lei Shi, Irene Drizin, et al.
Journal of Medicinal Chemistry
|
May 28, 2004
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a potent K(ATP) opener that selectively inhibits spontaneous bladder contractions
William A Carroll, Robert J Altenbach, Hao Bai, et al.
Communications Chemistry
|
August 16, 2024
Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex
Qi Hao, Manoj K Rathinaswamy, Kelly L Klinge, et al.
Pain
|
January 13, 2009
Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia
Prisca Honore, Prasant Chandran, Gricelda Hernandez, et al.
Journal of Medicinal Chemistry
|
March 6, 2023
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis <i>In Vivo</i>
John T Randolph, Matthew J O'Connor, Fei Han, et al.
Page
of 6