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Journal of Medicinal Chemistry|December 20, 2023
Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical AssessmentsAhmed A Al-Karmalawy, Mai H A Mousa, Marwa Sharaky, et al.
Bioorganic Chemistry|November 6, 2018
Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanomaAshraf A Aly, Essmat M El-Sheref, Momtaz E M Bakheet, et al.
Drug Development Research|November 17, 2025
Leveraging the Fragment Merging Approach for Synthetizing Novel Selanyl Phenyl Acetamide Thiazolidinedione Hybrids Endowed With Apoptotic Potential for Cancer TreatmentSaad Shaaban, Ayman Abo Elmaaty, Aya Yaseen Mahmood Alabdali, et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie|January 15, 2022
The dynamic interplay between AMPK/NFκB signaling and NLRP3 is a new therapeutic target in inflammation: Emerging role of dapagliflozin in overcoming lipopolysaccharide-mediated lung injuryEslam E Abd El-Fattah, Sameh Saber, Ahmed A E Mourad, et al.
International Immunopharmacology|August 27, 2024
Nicardipine-chitosan nanoparticles alleviate thioacetamide-induced acute liver injury by targeting NFκB/NLRP3/IL-1β signaling in rats: Unraveling new roles beyond calcium channel blockingAhmed Y Kira, Elsayed A Elmorsy, Rabab S Hamad, et al.
Frontiers in Pharmacology|January 31, 2022
AKT-AMPKα-mTOR-dependent HIF-1α Activation is a New Therapeutic Target for Cancer Treatment: A Novel Approach to Repositioning the Antidiabetic Drug Sitagliptin for the Management of Hepatocellular CarcinomaEslam E Abd El-Fattah, Sameh Saber, Mahmoud E Youssef, et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie|February 24, 2022
Coomassie brilliant blue G-250 dye attenuates bleomycin-induced lung fibrosis by regulating the NF-κB and NLRP3 crosstalk: A novel approach for filling an unmet medical needMona H Zohny, Simona Cavalu, Mahmoud E Youssef, et al.
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology|August 10, 2022
Ambroxol, a mucolytic agent, boosts HO-1, suppresses NF-κB, and decreases the susceptibility of the inflamed rat colon to apoptosis: A new treatment option for treating ulcerative colitisSimona Cavalu, Hossam Sharaf, Sameh Saber, et al.
Pharmaceuticals (Basel, Switzerland)|April 30, 2021
A Novel Combination Therapy Using Rosuvastatin and <i>Lactobacillus</i> Combats Dextran Sodium Sulfate-Induced Colitis in High-Fat Diet-Fed Rats by Targeting the TXNIP/NLRP3 Interaction and Influencing Gut Microbiome CompositionSameh Saber, Eslam E Abd El-Fattah, Galal Yahya, et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie|August 20, 2021
Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progressionSameh Saber, Mohamed Nasr, Ahmed S Saad, et al.
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