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Journal of Medicinal Chemistry|December 21, 2016
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide FunctionalityChristopher R Butler, Kevin Ogilvie, Luis Martinez-Alsina, et al.Nature Communications|October 12, 2016
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitorsAndrea M Zuhl, Charles E Nolan, Michael A Brodney, et al.The Journal of Pharmacology and Experimental Therapeutics|August 22, 2006
Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139Thomas A Lanz, Michael J Karmilowicz, Kathleen M Wood, et al.Asian Bioethics Review|July 11, 2026
Ethics and Regulation of Human Brain Organoid Research: Recommendations from the Asia Pacific Neuroethics Working GroupShu Ishida, Brett J Kagan, Masanori Kataoka, et al.Journal of Medicinal Chemistry|February 20, 2015
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug designChristopher R Butler, Michael A Brodney, Elizabeth M Beck, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|April 13, 2012
Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancerCharles M Rudin, Christine L Hann, Edward B Garon, et al.Journal of Medicinal Chemistry|October 15, 2011
Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitorsAntonia F Stepan, Kapil Karki, W Scott McDonald, et al.Critical Care Medicine|April 12, 2006
Effect of blood transfusion on outcome after major burn injury: a multicenter studyTina L Palmieri, Daniel M Caruso, Kevin N Foster, et al.Journal of Medicinal Chemistry|March 17, 2012
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitorAntonia F Stepan, Chakrapani Subramanyam, Ivan V Efremov, et al.Journal of Medicinal Chemistry|March 18, 2015
Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitorsMichael A Brodney, Elizabeth M Beck, Christopher R Butler, et al.Pageof 55