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Journal of General Internal Medicine|January 4, 2022
Implementation of an Intensive Telehealth Intervention for Rural Patients with Clinic-Refractory DiabetesElizabeth A Kobe, Allison A Lewinski, Amy S Jeffreys, et al.Bioorganic & Medicinal Chemistry Letters|January 29, 2011
Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: discovery of PF-3084014Michael A Brodney, David D Auperin, Stacey L Becker, et al.Contemporary Clinical Trials|September 24, 2020
Practical telehealth to improve control and engagement for patients with clinic-refractory diabetes mellitus (PRACTICE-DM): Protocol and baseline data for a randomized trialElizabeth A Kobe, David Edelman, Phillip E Tarkington, et al.Bioorganic & Medicinal Chemistry Letters|January 29, 2011
Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's diseaseMichael A Brodney, David D Auperin, Stacey L Becker, et al.Journal of Medicinal Chemistry|January 8, 2014
Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulatorLei Zhang, Gayatri Balan, Gabriela Barreiro, et al.Journal of Medicinal Chemistry|November 19, 2024
Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948Kevin J Filipski, Luis A Martinez-Alsina, Matthew R Reese, et al.Journal of Medicinal Chemistry|March 16, 2026
Discovery of Potent and Brain-Penetrant Inverse Agonists for GPR61, an Orphan G Protein-Coupled ReceptorEthan L Fisher, Anne-Marie Dechert Schmitt, Jamison B Tuttle, et al.Journal of Medicinal Chemistry|August 18, 2017
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman PrimatesAntonia F Stepan, Michelle M Claffey, Matthew R Reese, et al.Nature Communications|January 2, 2025
Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variantsMichelle R Garnsey, Yang Wang, David J Edmonds, et al.Science (New York, N.Y.)|November 2, 2021
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19Dafydd R Owen, Charlotte M N Allerton, Annaliesa S Anderson, et al.Pageof 36