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E W THOMAS

Showing results (81-90 of 95) with videos related to

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The Biochemical Journal|June 15, 1994
Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysis and reactions with time-dependent inhibitors: the Cys-25/His-159 ion-pair is insufficient for catalytic competence in both chymopapain M and papainM P Thomas, C M Topham, D Kowlessur, et al.
Journal of Medicinal Chemistry|April 3, 1992
Cholesterol lowering bile acid binding agents: novel lipophilic polyaminesE W Thomas, M M Cudahy, C H Spilman, et al.
The Biochemical Journal|May 15, 1987
Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bondingK Brocklehurst, D Kowlessur, M O'Driscoll, et al.
The Biochemical Journal|January 15, 1992
Variation in the P2-S2 stereochemical selectivity towards the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidinM Patel, I S Kayani, G W Mellor, et al.
Biochemical Society Transactions|February 1, 1997
Investigation of the electrostatic field of the papain active centre by using monoprotonated and diprotonated pyridyl (Py) disulphides as reactivity probesS Gul, A Clarke, B Field, et al.
The Biochemical Journal|January 1, 1989
The interplay of electrostatic and binding interactions determining active centre chemistry and catalytic activity in actinidin and papainK Brocklehurst, M O'Driscoll, D Kowlessur, et al.
The Biochemical Journal|March 15, 1988
Consequences of molecular recognition in the S1-S2 intersubsite region of papain for catalytic-site chemistry. Change in pH-dependence characteristics and generation of an inverse solvent kinetic isotope effect by introduction of a P1-P2 amide bond into a two-protonic-state reactivity probeK Brocklehurst, D Kowlessur, G Patel, et al.
Biochemical Society Transactions|August 1, 1990
Dynamic aspects of molecular recognition in cysteine proteinase-ligand systemsK Brocklehurst, E W Thomas, S Quenby, et al.
The Biochemical Journal|July 6, 2001
Variation in aspects of cysteine proteinase catalytic mechanism deduced by spectroscopic observation of dithioester intermediates, kinetic analysis and molecular dynamics simulationsJ D Reid, S Hussain, S K Sreedharan, et al.
Biochemical Society Transactions|July 3, 1998
The kinetically influential ionizations of caricain D158N revealed by using 4,4'-dipyrimidyl disulfide as a reactivity probeA Khan, I F Connerton, N J Cummings, et al.
Pageof 10

Showing results (81-90 of 95) with videos related to

Sort By:
Pageof 10
The Biochemical Journal|June 15, 1994
Structure of chymopapain M the late-eluted chymopapain deduced by comparative modelling techniques and active-centre characteristics determined by pH-dependent kinetics of catalysis and reactions with time-dependent inhibitors: the Cys-25/His-159 ion-pair is insufficient for catalytic competence in both chymopapain M and papainM P Thomas, C M Topham, D Kowlessur, et al.
Journal of Medicinal Chemistry|April 3, 1992
Cholesterol lowering bile acid binding agents: novel lipophilic polyaminesE W Thomas, M M Cudahy, C H Spilman, et al.
The Biochemical Journal|May 15, 1987
Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bondingK Brocklehurst, D Kowlessur, M O'Driscoll, et al.
The Biochemical Journal|January 15, 1992
Variation in the P2-S2 stereochemical selectivity towards the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidinM Patel, I S Kayani, G W Mellor, et al.
Biochemical Society Transactions|February 1, 1997
Investigation of the electrostatic field of the papain active centre by using monoprotonated and diprotonated pyridyl (Py) disulphides as reactivity probesS Gul, A Clarke, B Field, et al.
The Biochemical Journal|January 1, 1989
The interplay of electrostatic and binding interactions determining active centre chemistry and catalytic activity in actinidin and papainK Brocklehurst, M O'Driscoll, D Kowlessur, et al.
The Biochemical Journal|March 15, 1988
Consequences of molecular recognition in the S1-S2 intersubsite region of papain for catalytic-site chemistry. Change in pH-dependence characteristics and generation of an inverse solvent kinetic isotope effect by introduction of a P1-P2 amide bond into a two-protonic-state reactivity probeK Brocklehurst, D Kowlessur, G Patel, et al.
Biochemical Society Transactions|August 1, 1990
Dynamic aspects of molecular recognition in cysteine proteinase-ligand systemsK Brocklehurst, E W Thomas, S Quenby, et al.
The Biochemical Journal|July 6, 2001
Variation in aspects of cysteine proteinase catalytic mechanism deduced by spectroscopic observation of dithioester intermediates, kinetic analysis and molecular dynamics simulationsJ D Reid, S Hussain, S K Sreedharan, et al.
Biochemical Society Transactions|July 3, 1998
The kinetically influential ionizations of caricain D158N revealed by using 4,4'-dipyrimidyl disulfide as a reactivity probeA Khan, I F Connerton, N J Cummings, et al.
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