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Cancer Treatment and Research|November 17, 2023
WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI)Edmond M Chan, Kyla J Foster, Adam J BassBiotechnology and Bioengineering|January 5, 2010
Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleasesPei-Qi Liu, Edmond M Chan, Gregory J Cost, et al.Biorxiv : the Preprint Server for Biology|January 18, 2024
CRISPRmap: Sequencing-free optical pooled screens mapping multi-omic phenotypes in cells and tissueJiacheng Gu, Abhishek Iyer, Ben Wesley, et al.Nature Biotechnology|October 7, 2024
Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmapJiacheng Gu, Abhishek Iyer, Ben Wesley, et al.Nature|February 5, 2025
SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELOPatricia C Borck, Isabella Boyle, Kristina Jankovic, et al.Cancer Discovery|January 22, 2014
Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuitZehua Zhu, Amir R Aref, Travis J Cohoon, et al.Nature|October 1, 2020
Repeat expansions confer WRN dependence in microsatellite-unstable cancersNiek van Wietmarschen, Sriram Sridharan, William J Nathan, et al.Nature|October 23, 2009
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1David A Barbie, Pablo Tamayo, Jesse S Boehm, et al.Nature|April 12, 2019
WRN helicase is a synthetic lethal target in microsatellite unstable cancersEdmond M Chan, Tsukasa Shibue, James M McFarland, et al.Pageof 1