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Pharmaceutical Research|June 26, 2025
The Impact of Drug Properties and Severity of Obesity on Renal Drug Clearance Through Glomerular Filtration and Active Tubular Secretion: A Systematic Analysis Using PBPK ModelingTan Zhang, Elisa A M Calvier, Elke H J Krekels, et al.
The AAPS Journal|May 9, 2024
Impact of Obesity on Hepatic Drug Clearance: What are the Influential Variables?Tan Zhang, Elisa A M Calvier, Elke H J Krekels, et al.
Journal of Pharmacokinetics and Pharmacodynamics|June 15, 2020
Prior information for population pharmacokinetic and pharmacokinetic/pharmacodynamic analysis: overview and guidance with a focus on the NONMEM PRIOR subroutineAnna H-X P Chan Kwong, Elisa A M Calvier, David Fabre, et al.
CPT: Pharmacometrics & Systems Pharmacology|June 17, 2026
PMX-CovEval: A Framework Including a Simulated Pharmacokinetic Database for Covariate Model Building Methods BenchmarkingMélanie Karlsen, Jérôme Azé, Sandra Bringay, et al.
CPT: Pharmacometrics & Systems Pharmacology|January 29, 2019
Children Are Not Small Adults, but Can We Treat Them As Such?Elke H J Krekels, Elisa A M Calvier, Piet H van der Graaf, et al.
Pharmaceutical Research|October 14, 2025
Changes in the Fraction Metabolized in Children Younger than Four Years; When is Clearance Scaling for the Dominant Elimination Route in Adults Appropriate?Anne van Rongen, Robbin Grijseels, Elisa A M Calvier, et al.
Clinical Pharmacokinetics|March 25, 2018
The Influence of Normalization Weight in Population Pharmacokinetic Covariate ModelsSebastiaan C Goulooze, Swantje Völler, Pyry A J Välitalo, et al.
Expert Review of Clinical Pharmacology|June 9, 2016
Children in clinical trials: towards evidence-based pediatric pharmacotherapy using pharmacokinetic-pharmacodynamic modelingJanneke M Brussee, Elisa A M Calvier, Elke H J Krekels, et al.
Clinical Pharmacokinetics|August 12, 2016
Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?Elisa A M Calvier, Elke H J Krekels, Pyry A J Välitalo, et al.
Pharmaceutical Research|September 16, 2018
Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design TheoryElisa A M Calvier, Thu Thuy Nguyen, Trevor N Johnson, et al.
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