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Journal of Medicinal Chemistry|July 30, 2024
Structural and Physicochemical Features of Oral PROTACsMarkus Schade, James S Scott, Thomas G Hayhow, et al.Journal of Medicinal Chemistry|July 31, 2019
Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic MacrocyclesAmber Y S Balazs, Rodrigo J Carbajo, Nichola L Davies, et al.Angewandte Chemie (International Ed. in English)|March 30, 2021
Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt SignalingMathias Wendt, Rosa Bellavita, Alan Gerber, et al.Communications Biology|November 2, 2021
Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recyclingAlexander N Kapustin, Paul Davey, David Longmire, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Fragment-based discovery of 6-azaindazoles as inhibitors of bacterial DNA ligaseSteven Howard, Nader Amin, Andrew B Benowitz, et al.Bioorganic & Medicinal Chemistry Letters|August 12, 2011
Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disordersRomano Di Fabio, Annalisa Pellacani, Stefania Faedo, et al.Journal of Medicinal Chemistry|May 12, 2017
Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP)Emiliano Tamanini, Ildiko M Buck, Gianni Chessari, et al.Journal of Medicinal Chemistry|April 26, 2021
Fragment-Based Design of a Potent MAT2a Inhibitor and <i>in Vivo</i> Evaluation in an MTAP Null Xenograft ModelClaudia De Fusco, Marianne Schimpl, Ulf Börjesson, et al.Nature Communications|October 28, 2020
A protein tertiary structure mimetic modulator of the Hippo signalling pathwayHélène Adihou, Ranganath Gopalakrishnan, Tim Förster, et al.Cell Chemical Biology|December 2, 2019
EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 ComplexJessie Hao-Ru Hsu, Timothy Rasmusson, James Robinson, et al.Pageof 5