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Journal of Medicinal Chemistry|January 2, 2010
Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitorsYu-Sen Wang, Corey Strickland, Johannes H Voigt, et al.Journal of Medicinal Chemistry|January 2, 2010
Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validationZhaoning Zhu, Zhong-Yue Sun, Yuanzan Ye, et al.Bioorganic & Medicinal Chemistry Letters|March 7, 2012
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitorJared N Cumming, Elizabeth M Smith, Lingyan Wang, et al.Bioorganic & Medicinal Chemistry Letters|June 29, 2010
T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesisElizabeth M Smith, Steve Sorota, Hyunjin M Kim, et al.Bioorganic & Medicinal Chemistry Letters|October 24, 2006
2,6-Disubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitorsDmitri A Pissarnitski, Theodros Asberom, Thomas A Bara, et al.Pageof 3