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Nature Communications|May 15, 2023
GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapyLisa N Kasiewicz, Souvik Biswas, Aaron Beach, et al.Bioorganic & Medicinal Chemistry Letters|November 9, 2011
Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approachZhili Xin, Hairuo Peng, Andrew Zhang, et al.Bioorganic & Medicinal Chemistry Letters|March 2, 2010
Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugsBin Ma, Kevin M Guckian, Edward Yin-Shiang Lin, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase ModulatorHairuo Peng, Tina Talreja, Zhili Xin, et al.Neuropharmacology|December 23, 2015
BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's diseaseRobert H Scannevin, Sowmya Chollate, Melanie S Brennan, et al.Cell Reports|March 1, 2018
A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome EditingJonathan D Finn, Amy Rhoden Smith, Mihir C Patel, et al.Scientific Reports|September 9, 2018
Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic DysfunctionEdward Y S Lin, Laura F Silvian, Douglas J Marcotte, et al.Mabs|March 12, 2011
A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activityJianying Dong, Arlene Sereno, Dikran Aivazian, et al.Nature|May 20, 2021
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primatesKiran Musunuru, Alexandra C Chadwick, Taiji Mizoguchi, et al.Pageof 2