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Biorxiv : the Preprint Server for Biology|June 19, 2024
Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca<sup>2+</sup> and Mg<sup>2+</sup> in the formulationRachael Miller, Joseph Paquette, Alexandra Barker, et al.
Human Gene Therapy|July 25, 2025
Intrastriatal Delivery of a Zinc Finger Protein Targeting the Mutant HTT Gene Allele Obviates Lipid Phenotypes in Brain and Plasma in Huntington's Disease MiceAndrew Iwanowicz, Adel Boudi, Connor Seeley, et al.
Molecular Therapy. Nucleic Acids|November 18, 2024
Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca<sup>2+</sup> and Mg<sup>2+</sup> in the formulationRachael Miller, Joseph Paquette, Alexandra Barker, et al.
Molecular and Cellular Neurosciences|April 18, 2012
Multiple phenotypes in Huntington disease mouse neural stem cellsJames J Ritch, Antonio Valencia, Jonathan Alexander, et al.
Biorxiv : the Preprint Server for Biology|January 13, 2025
Detection of HTTex1p by western blot and immunostaining of HD human and mouse brain using neo-epitope antibody P90 highlights impact of CAG repeat expansion on its size, solubility, and response to MSH3 silencingEllen Sapp, Adel Boudi, Andrew Iwanowicz, et al.
Biorxiv : the Preprint Server for Biology|January 8, 2024
A programmable dual-targeting di-valent siRNA scaffold supports potent multi-gene modulation in the central nervous systemJillian Belgrad, Qi Tang, Sam Hildebrand, et al.
The Journal of Biological Chemistry|August 9, 2005
Huntingtin associates with acidic phospholipids at the plasma membraneKimberly B Kegel, Ellen Sapp, Jennifer Yoder, et al.
Nucleic Acids Research|May 10, 2024
A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous systemJillian Belgrad, Qi Tang, Sam Hildebrand, et al.
The Journal of Biological Chemistry|December 12, 2001
Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcriptionKimberly B Kegel, Alison R Meloni, Yong Yi, et al.
Brain Communications|September 10, 2025
Mutant huntingtin exon 1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MutS Homolog 3 silencing and aggregationEllen Sapp, Adel Boudi, Andrew Iwanowicz, et al.
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