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Matrix Biology Plus|February 5, 2021
Alterations in ECM signature underscore multiple sub-phenotypes of intervertebral disc degenerationTakashi Ohnishi, Emanuel J Novais, Makarand V Risbud
Matrix Biology : Journal of the International Society for Matrix Biology|February 28, 2019
p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescenceEmanuel J Novais, Brian O Diekman, Irving M Shapiro, et al.
Nature Reviews. Rheumatology|June 9, 2023
Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategiesSathish Muthu, Jasmijn V Korpershoek, Emanuel J Novais, et al.
Bone Research|April 13, 2026
Dasatinib and quercetin senolytic treatment delays early onset intervertebral disc degeneration in SM/J miceEmanuel J Novais, Olivia K Ottone, Sanjana Jagannath, et al.
Matrix Biology : Journal of the International Society for Matrix Biology|November 11, 2019
TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expressionSteven Tessier, Victoria A Tran, Olivia K Ottone, et al.
The American Journal of Pathology|December 11, 2020
Hypoxia and Hypoxia-Inducible Factor-1α Regulate Endoplasmic Reticulum Stress in Nucleus Pulposus Cells: Implications of Endoplasmic Reticulum Stress for Extracellular Matrix SecretionEmanuel J Novais, Hyowon Choi, Vedavathi Madhu, et al.
Bone Research|January 22, 2024
A new perspective on intervertebral disc calcification-from bench to bedsideEmanuel J Novais, Rajkishen Narayanan, Jose A Canseco, et al.
Nature Communications|September 4, 2021
Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in miceEmanuel J Novais, Victoria A Tran, Shira N Johnston, et al.
Aging Cell|April 23, 2020
Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc agingEmanuel J Novais, Victoria A Tran, Jingya Miao, et al.
Science Advances|April 23, 2025
Genetics- and age-driven neuroimmune and disc changes underscore herniation susceptibility and pain-associated behaviors in SM/J miceEmanuel J Novais, Olivia K Ottone, Eric V Brown, et al.
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