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Diabetes|July 7, 2016
The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP LevelsSimon A Hawley, Rebecca J Ford, Brennan K Smith, et al.
Molecular Metabolism|July 11, 2019
GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injuryKhrystyna Platko, Paul F Lebeau, Jae Hyun Byun, et al.
The Journal of Biological Chemistry|March 25, 2022
Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite-binding siteMatthew J Sanders, Yann Ratinaud, Katyayanee Neopane, et al.
Nature Communications|January 25, 2020
Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistanceJulian M Yabut, Eric M Desjardins, Eric J Chan, et al.
Nature Communications|November 29, 2016
Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosisStephen L Pinkosky, Roger S Newton, Emily A Day, et al.
Journal of Lipid Research|March 17, 2015
Salicylate improves macrophage cholesterol homeostasis via activation of AmpkMorgan D Fullerton, Rebecca J Ford, Chelsea P McGregor, et al.
Molecular Metabolism|August 23, 2021
Salsalate reduces atherosclerosis through AMPKβ1 in miceEmily A Day, Rebecca J Ford, Brennan K Smith, et al.
Proceedings of the National Academy of Sciences of the United States of America|November 21, 2022
The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acidsEric M Desjardins, Brennan K Smith, Emily A Day, et al.
The Biochemical Journal|March 6, 2015
Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivityRebecca J Ford, Morgan D Fullerton, Stephen L Pinkosky, et al.
Iscience|November 29, 2023
Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in miceEmily A Day, Logan K Townsend, Sonia Rehal, et al.
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