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Biochemistry|September 7, 2010
Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrelSean C Gay, Arthur G Roberts, Keiko Maekawa, et al.
The Journal of Biological Chemistry|October 17, 2012
Stereoselective formation and metabolism of 4-hydroxy-retinoic Acid enantiomers by cytochrome p450 enzymesJakob A Shimshoni, Arthur G Roberts, Michele Scian, et al.
Biochemistry|December 30, 2014
Concurrent cooperativity and substrate inhibition in the epoxidation of carbamazepine by cytochrome P450 3A4 active site mutants inspired by molecular dynamics simulationsChristian S Müller, Tim Knehans, Dmitri R Davydov, et al.
The Journal of Biological Chemistry|March 12, 2020
Structure of an ancestral mammalian family 1B1 cytochrome P450 with increased thermostabilityAaron G Bart, Kurt L Harris, Elizabeth M J Gillam, et al.
Organic & Biomolecular Chemistry|September 15, 2021
Effects of fluorine substitution on substrate conversion by cytochromes P450 17A1 and 21A2Caleb D Vogt, Aaron G Bart, Rahul Yadav, et al.
Methods in Enzymology|October 6, 2023
Generation of human steroidogenic cytochrome P450 enzymes for structural and functional characterizationSarah D Burris-Hiday, Cara L Loomis, Alaina M Richard, et al.
Chemical Research in Toxicology|November 16, 2007
Differential time-dependent inactivation of P450 3A4 and P450 3A5 by raloxifene: a key role for C239 in quenching reactive intermediatesJosh T Pearson, Jan L Wahlstrom, Leslie J Dickmann, et al.
Biochemistry|January 2, 2013
Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysisHaoming Zhang, Sean C Gay, Manish Shah, et al.
Molecular Pharmacology|January 31, 2016
Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic MetabolismManish B Shah, Jingbao Liu, Lu Huo, et al.
Journal of Medicinal Chemistry|May 25, 2018
Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2Charlie Fehl, Caleb D Vogt, Rahul Yadav, et al.
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