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Science Translational Medicine|March 4, 2016
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent modelsSaravanan S Karuppagounder, Ishraq Alim, Soah J Khim, et al.Antimicrobial Agents and Chemotherapy|May 29, 2026
Standardized numbering and alignment of the KPC family of β-lactamasesFlorencia Brunetti, Steven H Marshall, Christopher R Bethel, et al.Cell|April 2, 2026
Rational discovery of therapeutic PAK1 allosteric activatorsYu He, James S H Bae, Elżbieta Nowak, et al.Chemical Science|December 19, 2015
5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron TranslocationRichard J Hopkinson, Anthony Tumber, Clarence Yapp, et al.Journal of Medicinal Chemistry|June 26, 2012
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylasesNathan R Rose, Esther C Y Woon, Anthony Tumber, et al.Nature Communications|July 23, 2021
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallographyAgata Butryn, Philipp S Simon, Pierre Aller, et al.Journal of Medicinal Chemistry|January 8, 2016
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase InhibitorsVassilios Bavetsias, Rachel M Lanigan, Gian Filippo Ruda, et al.Science Advances|August 21, 2021
X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysisPatrick Rabe, Jos J A G Kamps, Kyle D Sutherlin, et al.Nature Chemistry|December 14, 2021
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitorsJürgen Brem, Tharindi Panduwawala, Jon Ulf Hansen, et al.Science (New York, N.Y.)|November 9, 2023
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitorsMelissa L Boby, Daren Fearon, Matteo Ferla, et al.Pageof 59