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ACS Medicinal Chemistry Letters
|
September 17, 2025
Characterization of Next-Generation Inhibitors for the Inward-Rectifier Potassium Channel K<sub>ir</sub>2.1: Discovery of VU6080824
Renn A Duncan, Daniel H Haymer, Roman M Lazarenko, et al.
Bioorganic & Medicinal Chemistry Letters
|
March 26, 2023
Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS
Cayden J Dodd, Keagan S Chronister, Upendra Rathnayake, et al.
Journal of Medicinal Chemistry
|
November 26, 2014
Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)
Lindsey C Morris, Kellie D Nance, Patrick R Gentry, et al.
Molecular Pharmacology
|
June 10, 2026
Identification of potent and selective small molecule TALK-1 inhibitors that promote β-cell function
Arya Y Nakhe, Jordyn R Dobson, Prasanna K Dadi, et al.
Molecular Pharmacology
|
March 5, 2022
VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels
Samantha J McClenahan, Caitlin N Kent, Sujay V Kharade, et al.
Molecular Pharmacology
|
December 3, 2008
Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity
Joy E Marlo, Colleen M Niswender, Emily L Days, et al.
Molecular Pharmacology
|
July 31, 2008
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4
Colleen M Niswender, Kari A Johnson, C David Weaver, et al.
Biorxiv : the Preprint Server for Biology
|
November 24, 2025
High Throughput Screening Identifies a Small Molecule Trafficking Corrector for Long-QT Syndrome Associated KCNQ1 Variants
Katherine R Clowes Moster, Carlos G Vanoye, Ana C Chang-Gonzalez, et al.
JCI Insight
|
January 8, 2026
High throughput screening identifies a trafficking corrector for long-QT syndrome associated KCNQ1 variants
Katherine R Clowes Moster, Carlos G Vanoye, Ana C Chang-Gonzalez, et al.
Molecular Pharmacology
|
October 7, 2010
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity
Alice L Rodriguez, Mark D Grier, Carrie K Jones, et al.
Page
of 3
Search research articles
Search
Showing results (11-20 of 21) with videos related to
Sort By:
Page
of 3
ACS Medicinal Chemistry Letters
|
September 17, 2025
Characterization of Next-Generation Inhibitors for the Inward-Rectifier Potassium Channel K<sub>ir</sub>2.1: Discovery of VU6080824
Renn A Duncan, Daniel H Haymer, Roman M Lazarenko, et al.
Bioorganic & Medicinal Chemistry Letters
|
March 26, 2023
Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS
Cayden J Dodd, Keagan S Chronister, Upendra Rathnayake, et al.
Journal of Medicinal Chemistry
|
November 26, 2014
Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)
Lindsey C Morris, Kellie D Nance, Patrick R Gentry, et al.
Molecular Pharmacology
|
June 10, 2026
Identification of potent and selective small molecule TALK-1 inhibitors that promote β-cell function
Arya Y Nakhe, Jordyn R Dobson, Prasanna K Dadi, et al.
Molecular Pharmacology
|
March 5, 2022
VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels
Samantha J McClenahan, Caitlin N Kent, Sujay V Kharade, et al.
Molecular Pharmacology
|
December 3, 2008
Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity
Joy E Marlo, Colleen M Niswender, Emily L Days, et al.
Molecular Pharmacology
|
July 31, 2008
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4
Colleen M Niswender, Kari A Johnson, C David Weaver, et al.
Biorxiv : the Preprint Server for Biology
|
November 24, 2025
High Throughput Screening Identifies a Small Molecule Trafficking Corrector for Long-QT Syndrome Associated KCNQ1 Variants
Katherine R Clowes Moster, Carlos G Vanoye, Ana C Chang-Gonzalez, et al.
JCI Insight
|
January 8, 2026
High throughput screening identifies a trafficking corrector for long-QT syndrome associated KCNQ1 variants
Katherine R Clowes Moster, Carlos G Vanoye, Ana C Chang-Gonzalez, et al.
Molecular Pharmacology
|
October 7, 2010
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity
Alice L Rodriguez, Mark D Grier, Carrie K Jones, et al.
Page
of 3