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ACS Medicinal Chemistry Letters
|
March 21, 2019
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481
Kenneth M Boy, Jason M Guernon, Dmitry S Zuev, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
May 19, 2016
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects
Jeremy H Toyn, Kenneth M Boy, Joseph Raybon, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
January 1, 2013
Pharmacodynamics of selective inhibition of γ-secretase by avagacestat
Charles F Albright, Randy C Dockens, Jere E Meredith, et al.
The Journal of Biological Chemistry
|
June 25, 2008
The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression
Catherine R Burton, Jere E Meredith, Donna M Barten, et al.
Nature Medicine
|
January 22, 2019
Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
Morgan L Maeder, Michael Stefanidakis, Christopher J Wilson, et al.
Molecular Therapy. Nucleic Acids
|
September 12, 2022
Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies
Amy Easton, Marianne L Jensen, Congwei Wang, et al.
Journal of Medicinal Chemistry
|
March 9, 2022
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain
Guanglin Luo, Ling Chen, Walter A Kostich, et al.
International Journal of Alzheimer'S Disease
|
August 7, 2014
Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780
Jeremy H Toyn, Lorin A Thompson, Kimberley A Lentz, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
September 29, 2017
Preclinical Characterization of (<i>R</i>)-3-((3<i>S</i>,4<i>S</i>)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate <i>N</i>-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder
Linda J Bristow, Jyoti Gulia, Michael R Weed, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
July 15, 2016
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
Walter Kostich, Brian D Hamman, Yu-Wen Li, et al.
Page
of 14
Search research articles
Search
Showing results (121-130 of 131) with videos related to
Sort By:
Page
of 14
ACS Medicinal Chemistry Letters
|
March 21, 2019
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481
Kenneth M Boy, Jason M Guernon, Dmitry S Zuev, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
May 19, 2016
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects
Jeremy H Toyn, Kenneth M Boy, Joseph Raybon, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
January 1, 2013
Pharmacodynamics of selective inhibition of γ-secretase by avagacestat
Charles F Albright, Randy C Dockens, Jere E Meredith, et al.
The Journal of Biological Chemistry
|
June 25, 2008
The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression
Catherine R Burton, Jere E Meredith, Donna M Barten, et al.
Nature Medicine
|
January 22, 2019
Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
Morgan L Maeder, Michael Stefanidakis, Christopher J Wilson, et al.
Molecular Therapy. Nucleic Acids
|
September 12, 2022
Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies
Amy Easton, Marianne L Jensen, Congwei Wang, et al.
Journal of Medicinal Chemistry
|
March 9, 2022
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain
Guanglin Luo, Ling Chen, Walter A Kostich, et al.
International Journal of Alzheimer'S Disease
|
August 7, 2014
Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780
Jeremy H Toyn, Lorin A Thompson, Kimberley A Lentz, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
September 29, 2017
Preclinical Characterization of (<i>R</i>)-3-((3<i>S</i>,4<i>S</i>)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate <i>N</i>-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder
Linda J Bristow, Jyoti Gulia, Michael R Weed, et al.
The Journal of Pharmacology and Experimental Therapeutics
|
July 15, 2016
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
Walter Kostich, Brian D Hamman, Yu-Wen Li, et al.
Page
of 14