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Plos Biology|March 22, 2017
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chainNathanael G Lintner, Kim F McClure, Donna Petersen, et al.
The Journal of Biological Chemistry|April 28, 2000
Identification, characterization, and crystal structure of the Omega class glutathione transferasesP G Board, M Coggan, G Chelvanayagam, et al.
Nature Structural & Molecular Biology|April 17, 2007
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemiaDavid Cunningham, Dennis E Danley, Kieran F Geoghegan, et al.
Nature Communications|October 12, 2016
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitorsAndrea M Zuhl, Charles E Nolan, Michael A Brodney, et al.
The Journal of Pharmacology and Experimental Therapeutics|April 6, 2010
Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014Thomas A Lanz, Kathleen M Wood, Karl E G Richter, et al.
The Journal of Pharmacology and Experimental Therapeutics|August 22, 2006
Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139Thomas A Lanz, Michael J Karmilowicz, Kathleen M Wood, et al.
Bioorganic & Medicinal Chemistry Letters|May 7, 2002
Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitorsMichael A Letavic, Matt Z Axt, John T Barberia, et al.
Scientific Reports|August 17, 2016
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonistsShenping Liu, Leslie A Dakin, Li Xing, et al.
Ebiomedicine|April 21, 2018
Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical ModelsRyan M Esquejo, Christopher T Salatto, Jake Delmore, et al.
The Journal of Pharmacology and Experimental Therapeutics|February 14, 2012
Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivoRobin J Kleiman, Douglas S Chapin, Curt Christoffersen, et al.
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