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The Journal of Pharmacology and Experimental Therapeutics
|
May 4, 2023
A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6<sup>+</sup> T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
Wei Li, Kimberly K Crouse, Jennifer Alley, et al.
Journal of Medicinal Chemistry
|
December 30, 2021
Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1
Agustin Casimiro-Garcia, Christophe Allais, Agnes Brennan, et al.
Nature Communications
|
May 16, 2025
Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca<sup>2+</sup> dependent allosteric binding site
Leslie A Dakin, Li Xing, Justin Hall, et al.
Scientific Reports
|
August 17, 2016
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
Shenping Liu, Leslie A Dakin, Li Xing, et al.
Plos One
|
September 22, 2017
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
Justin Hall, Amy Brault, Fabien Vincent, et al.
ACS Chemical Biology
|
October 30, 2016
Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition
Jean-Baptiste Telliez, Martin E Dowty, Lu Wang, et al.
Nature Communications
|
August 31, 2024
Structural basis for CCR6 modulation by allosteric antagonists
David Jonathan Wasilko, Brian S Gerstenberger, Kathleen A Farley, et al.
Journal of Medicinal Chemistry
|
August 17, 2018
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)
Andrew Fensome, Catherine M Ambler, Eric Arnold, et al.
Nature Communications
|
March 10, 2026
Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis
Jennifer L Duffen, Kimberly K Crouse, Lin Ji, et al.
Journal of Medicinal Chemistry
|
September 22, 2025
Discovery of PF-07054894, a Potent Squaramide-Based CCR6 Antagonist Displaying High CXCR2 Selectivity
Mark E Schnute, Huixian Wu, John I Trujillo, et al.
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of 5
Search research articles
Search
Showing results (31-40 of 42) with videos related to
Sort By:
Page
of 5
The Journal of Pharmacology and Experimental Therapeutics
|
May 4, 2023
A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6<sup>+</sup> T Cells, and Ameliorates Interleukin-23-Induced Skin Inflammation
Wei Li, Kimberly K Crouse, Jennifer Alley, et al.
Journal of Medicinal Chemistry
|
December 30, 2021
Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1
Agustin Casimiro-Garcia, Christophe Allais, Agnes Brennan, et al.
Nature Communications
|
May 16, 2025
Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca<sup>2+</sup> dependent allosteric binding site
Leslie A Dakin, Li Xing, Justin Hall, et al.
Scientific Reports
|
August 17, 2016
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
Shenping Liu, Leslie A Dakin, Li Xing, et al.
Plos One
|
September 22, 2017
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
Justin Hall, Amy Brault, Fabien Vincent, et al.
ACS Chemical Biology
|
October 30, 2016
Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition
Jean-Baptiste Telliez, Martin E Dowty, Lu Wang, et al.
Nature Communications
|
August 31, 2024
Structural basis for CCR6 modulation by allosteric antagonists
David Jonathan Wasilko, Brian S Gerstenberger, Kathleen A Farley, et al.
Journal of Medicinal Chemistry
|
August 17, 2018
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)
Andrew Fensome, Catherine M Ambler, Eric Arnold, et al.
Nature Communications
|
March 10, 2026
Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis
Jennifer L Duffen, Kimberly K Crouse, Lin Ji, et al.
Journal of Medicinal Chemistry
|
September 22, 2025
Discovery of PF-07054894, a Potent Squaramide-Based CCR6 Antagonist Displaying High CXCR2 Selectivity
Mark E Schnute, Huixian Wu, John I Trujillo, et al.
Page
of 5