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Journal of Chemical Information and Modeling
|
February 26, 2016
Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening
Elumalai Pavadai, Farah El Mazouni, Sergio Wittlin, et al.
Journal of Medicinal Chemistry
|
June 5, 2008
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum
Margaret A Phillips, Ramesh Gujjar, Nicholas A Malmquist, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 10, 2010
Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif
Nina Klee, Pui Ee Wong, Beatriz Baragaña, et al.
The Journal of Biological Chemistry
|
July 31, 2009
Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds
Xiaoyi Deng, Ramesh Gujjar, Farah El Mazouni, et al.
Journal of Medicinal Chemistry
|
August 11, 2012
Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase
Alka Marwaha, John White, Farah El Mazouni, et al.
Journal of Medicinal Chemistry
|
May 8, 2014
Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors
Xiaoyi Deng, Sreekanth Kokkonda, Farah El Mazouni, et al.
Journal of Medicinal Chemistry
|
March 20, 2009
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice
Ramesh Gujjar, Alka Marwaha, Farah El Mazouni, et al.
Journal of Medicinal Chemistry
|
June 17, 2015
Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)
Marianne Lucas-Hourani, Hélène Munier-Lehmann, Farah El Mazouni, et al.
ACS Infectious Diseases
|
October 31, 2018
Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265
John White, Satish K Dhingra, Xiaoyi Deng, et al.
Journal of Medicinal Chemistry
|
March 23, 2012
Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials
Yiqun Zhang, Julie A Clark, Michele C Connelly, et al.
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Search research articles
Search
Showing results (1-10 of 21) with videos related to
Sort By:
Page
of 3
Journal of Chemical Information and Modeling
|
February 26, 2016
Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening
Elumalai Pavadai, Farah El Mazouni, Sergio Wittlin, et al.
Journal of Medicinal Chemistry
|
June 5, 2008
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum
Margaret A Phillips, Ramesh Gujjar, Nicholas A Malmquist, et al.
Bioorganic & Medicinal Chemistry Letters
|
July 10, 2010
Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif
Nina Klee, Pui Ee Wong, Beatriz Baragaña, et al.
The Journal of Biological Chemistry
|
July 31, 2009
Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds
Xiaoyi Deng, Ramesh Gujjar, Farah El Mazouni, et al.
Journal of Medicinal Chemistry
|
August 11, 2012
Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase
Alka Marwaha, John White, Farah El Mazouni, et al.
Journal of Medicinal Chemistry
|
May 8, 2014
Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors
Xiaoyi Deng, Sreekanth Kokkonda, Farah El Mazouni, et al.
Journal of Medicinal Chemistry
|
March 20, 2009
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice
Ramesh Gujjar, Alka Marwaha, Farah El Mazouni, et al.
Journal of Medicinal Chemistry
|
June 17, 2015
Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)
Marianne Lucas-Hourani, Hélène Munier-Lehmann, Farah El Mazouni, et al.
ACS Infectious Diseases
|
October 31, 2018
Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265
John White, Satish K Dhingra, Xiaoyi Deng, et al.
Journal of Medicinal Chemistry
|
March 23, 2012
Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials
Yiqun Zhang, Julie A Clark, Michele C Connelly, et al.
Page
of 3