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Journal of Medicinal Chemistry|September 19, 2012
Spirocyclic sulfamides as β-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitorsMichael A Brodney, Gabriela Barreiro, Kevin Ogilvie, et al.Journal of Medicinal Chemistry|November 14, 2018
Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent InhibitorsAgustin Casimiro-Garcia, John I Trujillo, Felix Vajdos, et al.Cancer Research|March 15, 2008
Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271Walter Gregory Roberts, Ethan Ung, Pamela Whalen, et al.Journal of Medicinal Chemistry|December 21, 2016
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide FunctionalityChristopher R Butler, Kevin Ogilvie, Luis Martinez-Alsina, et al.ACS Chemical Biology|September 24, 2024
Discovery, Characterization, and Structure of a Cell Active PAD2 Inhibitor Acting through a Novel Allosteric MechanismLaura J Byrnes, Won Young Choi, Paul Balbo, et al.Bioorganic & Medicinal Chemistry Letters|March 12, 2010
Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2Jeffrey W Corbett, Kevin D Freeman-Cook, Richard Elliott, et al.Journal of Medicinal Chemistry|February 1, 2017
Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in HumansAtli Thorarensen, Martin E Dowty, Mary Ellen Banker, et al.Journal of Medicinal Chemistry|February 20, 2015
Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug designChristopher R Butler, Michael A Brodney, Elizabeth M Beck, et al.Pageof 1