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Toxicological Sciences : an Official Journal of the Society of Toxicology|February 21, 2020
A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus MonkeysMayur S Mitra, Karla Lancaster, Adeyemi O Adedeji, et al.
Molecular Cancer Therapeutics|December 4, 2020
An Anti-CD22-seco-CBI-Dimer Antibody-Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical ModelsShang-Fan Yu, Donna W Lee, Bing Zheng, et al.
The Journal of Pharmacology and Experimental Therapeutics|November 9, 2016
Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in RatsRebecca I Erickson, Leah K Schutt, Jacqueline M Tarrant, et al.
Molecular Cancer Therapeutics|March 16, 2021
Calicheamicin Antibody-Drug Conjugates with Improved PropertiesBreanna S Vollmar, Chris Frantz, Melissa M Schutten, et al.
Molecular Cancer Therapeutics|December 29, 2017
An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast CancerSunil Bhakta, Lisa M Crocker, Yvonne Chen, et al.
JCI Insight|April 10, 2020
Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibodyKarin Staflin, Christina L Zuch de Zafra, Leah K Schutt, et al.
Molecular Cancer Therapeutics|February 23, 2017
Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide LinkersThomas H Pillow, Melissa Schutten, Shang-Fan Yu, et al.
Bioconjugate Chemistry|April 11, 2019
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In VivoDian Su, Jinhua Chen, Ely Cosino, et al.
Journal of Medicinal Chemistry|March 3, 2024
Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory DiseaseJack A Terrett, Justin Q Ly, Paula Katavolos, et al.
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