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Antiviral Therapy|May 18, 2023
A single, oral dose of the TLR7 agonist JNJ-64794964 induces transcriptomic and phenotypic changes in peripheral immune cells in healthy adultsWim Pierson, Marianne Tuefferd, Florence Herschke, et al.Bioorganic & Medicinal Chemistry Letters|August 26, 2018
Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonistsDavid C McGowan, Florence Herschke, Mourad D Khamlichi, et al.Journal of Medicinal Chemistry|August 12, 2016
Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B VirusDavid McGowan, Florence Herschke, Frederik Pauwels, et al.Bioorganic & Medicinal Chemistry Letters|January 26, 2018
Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonistsSerge Pieters, David McGowan, Florence Herschke, et al.Journal of Medicinal Chemistry|July 3, 2018
2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B VirusWerner Embrechts, Florence Herschke, Frederik Pauwels, et al.Journal of Medicinal Chemistry|August 6, 2024
Discovery of gem-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase InhibitorsSandrine Grosse, Ludwig Cooymans, Werner Embrechts, et al.Journal of Medicinal Chemistry|June 27, 2024
Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus InfectionsBart Kesteleyn, Florence Herschke, Nicolas Darville, et al.Journal of Medicinal Chemistry|July 4, 2017
Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis BDavid C McGowan, Florence Herschke, Frederik Pauwels, et al.Communications Biology|October 21, 2023
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitorXiaodi Yu, Pravien Abeywickrema, Brecht Bonneux, et al.Antiviral Research|May 21, 2024
JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymeraseBrecht Bonneux, Afzaal Shareef, Sergey Tcherniuk, et al.Pageof 2