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The EMBO Journal|November 12, 2024
Determinants of chemoselectivity in ubiquitination by the J2 family of ubiquitin-conjugating enzymesAnuruti Swarnkar, Florian Leidner, Ashok K Rout, et al.
ACS Infectious Diseases|December 14, 2018
Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 ProteaseGordon J Lockbaum, Florian Leidner, Linah N Rusere, et al.
Biochemistry|August 7, 2019
Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in ResistanceMina Henes, Klajdi Kosovrasti, Gordon J Lockbaum, et al.
ACS Chemical Biology|July 31, 2019
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug ResistanceMina Henes, Gordon J Lockbaum, Klajdi Kosovrasti, et al.
Angewandte Chemie (International Ed. in English)|June 19, 2025
Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual StereocontrolGaurav P Kudalkar, Florian Leidner, Nivesh Kumar, et al.
Science Advances|October 15, 2025
Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearingHan Chen, Constantin Cretu, Abigail Trebilcock, et al.
Chemical Reviews|January 7, 2021
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and BeyondAshley N Matthew, Florian Leidner, Gordon J Lockbaum, et al.
Nature Communications|September 2, 2025
Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1Barbara Orth, Pavel Pohl, Florian Aust, et al.
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